Molecular Brain
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#1Anne-Sophie Racine (UdeM: Université de Montréal)H-Index: 2
#2François-Xavier Michon (UdeM: Université de Montréal)
Last. Jean-Claude Lacaille (UdeM: Université de Montréal)H-Index: 60
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Somatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receive excitation from pyramidal cells (PCs), and, in turn, provide feedback inhibition onto PC dendrites. Excitatory synapses onto SOM-INs show a Hebbian long-term potentiation (LTP) mediated by type 1a metabotropic glutamate receptors (mGluR1a) that is implicated in hippocampus-dependent learning. The neuropeptide somatostatin (SST) is also critical for hippocampal long-term syn...
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#2Huanyu LuH-Index: 2
Last. Wenjing Luo (Fourth Military Medical University)H-Index: 28
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#1Makoto Asahina (Takeda Pharmaceutical Company)H-Index: 3
#2Reiko FujinawaH-Index: 1
Last. Tadashi Suzuki (Takeda Pharmaceutical Company)H-Index: 3
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#1Robin N. Stringer (CAS: Academy of Sciences of the Czech Republic)H-Index: 2
#2Bohumila Jurkovicova-Tarabova (SAV: Slovak Academy of Sciences)H-Index: 4
Last. Norbert WeissH-Index: 20
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Developmental and epileptic encephalopathies (DEEs) are a group of severe epilepsies that are characterized by seizures and developmental delay. DEEs are primarily attributed to genetic causes and an increasing number of cases have been correlated with variants in ion channel genes. In this study, we report a child with an early severe DEE. Whole exome sequencing showed a de novo heterozygous variant (c.4873-4881 duplication) in the SCN8A gene and an inherited heterozygous variant (c.952G > A) i...
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#1Marie E. Gaine (UI: University of Iowa)H-Index: 3
#2Ethan Bahl (UI: University of Iowa)H-Index: 3
Last. Lisa C. Lyons (Roy J. and Lucille A. Carver College of Medicine)H-Index: 19
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Widespread sleep deprivation is a continuing public health problem in the United States and worldwide affecting adolescents and adults. Acute sleep deprivation results in decrements in spatial memory and cognitive impairments. The hippocampus is vulnerable to acute sleep deprivation with changes in gene expression, cell signaling, and protein synthesis. Sleep deprivation also has long lasting effects on memory and performance that persist after recovery sleep, as seen in behavioral studies from ...
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#1Wen-bo Chen (NKU: Nankai University)H-Index: 2
#2Yu-xiang Wang (Hebei University)
Last. Yan-Qiang Liu (NKU: Nankai University)H-Index: 11
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To understand the role of intracellular zinc ion (Zn2+) dysregulation in mediating age-related neurodegenerative changes, particularly neurotoxicity resulting from the generation of excessive neurotoxic amyloid-β (Aβ) peptides, this study aimed to investigate whether N, N, N', N'-tetrakis (2-pyridylmethyl) ethylenediamine (TPEN), a Zn2+-specific chelator, could attenuate Aβ25-35-induced neurotoxicity and the underlying electrophysiological mechanism. We used the 3-(4, 5-dimethyl-thiazol-2-yl)-2,...
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#1Yuan Yao (JLU: Jilin University)H-Index: 1
#2Yingshi Ji (JLU: Jilin University)H-Index: 5
Last. Li Sun (JLU: Jilin University)H-Index: 5
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Cerebral ischemia, a common cerebrovascular disease, is characterized by functional deficits and apoptotic cell death. Autophagy, a type of programmed cell death, plays critical roles in controlling neuronal damage and metabolic homeostasis, and has been inextricably linked to cerebral ischemia. We previously identified a short peptide aptamer from collapsin response mediator protein 2 (CRMP2), designated the Ca2+ channel-binding domain 3 (CBD3) peptide, that conferred protection against excitot...
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#1Tae-Young HaH-Index: 1
#2Yu Ree ChoiH-Index: 5
Last. Sang Myun ParkH-Index: 21
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#1Haiwang Zhang (U of T: University of Toronto)
#2Youssif Ben Zablah (U of T: University of Toronto)
Last. Zhengping Jia (U of T: University of Toronto)H-Index: 31
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Accumulating evidence indicates that the actin regulator cofilin is overactivated in Alzheimer's Disease (AD), but whether this abnormality contributes to synaptic and cognitive impairments in AD is unclear. In addition, the brain region and cell types involved remain unknown. In this study, we specifically manipulate LIMK1, the key protein kinase that phosphorylates and inactivates cofilin, in the hippocampus of APP/PS1 transgenic mice. Using local injections of the AAV virus containing LIMK1 u...
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#1Arpna Srivastava (AIIMS, New Delhi)H-Index: 14
#2Krishan Kumar (DU: University of Delhi)H-Index: 14
Last. Ramesh Doddamani (AIIMS, New Delhi)H-Index: 1
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Focal cortical dysplasia (FCD) is a malformation of the cerebral cortex with poorly-defined epileptogenic zones (EZs), and poor surgical outcome in FCD is associated with inaccurate localization of the EZ. Hence, identifying novel epileptogenic markers to aid in the localization of EZ in patients with FCD is very much needed. High-throughput gene expression studies of FCD samples have the potential to uncover molecular changes underlying the epileptogenic process and identify novel markers for d...
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Top fields of study
Psychopharmacology
Endocrinology
Hippocampal formation
Neuroscience
Chemistry
Hippocampus
Biology
Cell biology