Detection performance analysis for time-of-flight PET

In this paper, we investigate the performance of time-of-flight (TOF) positron emission tomography (PET) in improving lesion detectability. We present a theoretical approach to compare lesion detectability of TOF versus non-TOF systems and perform computer simulations to validate the theoretical prediction. A single-ring TOF PET tomograph is simulated using SimSET software, and images are reconstructed in 2D from list-mode data using a maximum a...