Ronald H. Huesman
Lawrence Berkeley National Laboratory
Imaging phantomAlgorithmOpticsPhysicsIterative reconstructionArtificial intelligenceTomographyMonte Carlo methodMedical physicsImage resolutionPositron emission tomographySingle-photon emission computed tomographyNuclear medicineComputer visionMathematicsComputer scienceMedicineImage processingDetector
94Publications
33H-index
1,712Citations
Publications 120
Newest
#1Suzanne L. Baker (LBNL: Lawrence Berkeley National Laboratory)H-Index: 39
#2Samuel N. Lockhart (HWNI: Helen Wills Neuroscience Institute)H-Index: 21
Last. William J. Jagust (HWNI: Helen Wills Neuroscience Institute)H-Index: 143
view all 9 authors...
Author(s): Baker, SL; Lockhart, SN; Price, JC; He, M; Huesman, RH; Schonhaut, D; Faria, J; Rabinovici, G; Jagust, WJ | Abstract: Copyright © 2017 SNMMI; all rights reserved. The goal of this paper was to evaluate the in vivo kinetics of the novel tau-specific PET radioligand 18F-AV-1451 in cognitively healthy control (HC) and Alzheimer disease (AD) subjects, using reference region analyses. Methods: 18F-AV-1451 PET imaging was performed on 43 subjects (5 young HCs, 23 older HCs, and 15 AD subjec...
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#7Ronald H. HuesmanH-Index: 33
#1Qiyu Peng (LBNL: Lawrence Berkeley National Laboratory)H-Index: 10
#2Woon-Seng Choong (LBNL: Lawrence Berkeley National Laboratory)H-Index: 22
Last. William W. Moses (LBNL: Lawrence Berkeley National Laboratory)H-Index: 57
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We have constructed and characterized a time-of-flight Positron Emission Tomography (TOF PET) camera called the Tachyon. The Tachyon is a single-ring Lutetium Oxyorthosilicate (LSO) based camera designed to obtain significantly better timing resolution than the \sim 550~\hbox{ps}found in present commercial TOF cameras, in order to quantify the benefit of improved TOF resolution for clinically relevant tasks. The Tachyon’s detector module is optimized for timing by coupling the $6.15 \times 25...
Source
#1Qiyu Peng (LBNL: Lawrence Berkeley National Laboratory)H-Index: 10
#2Woon-Seng Choong (LBNL: Lawrence Berkeley National Laboratory)H-Index: 22
Last. William W. Moses (LBNL: Lawrence Berkeley National Laboratory)H-Index: 57
view all 8 authors...
Tachyon, a single-ring “demonstration” Time-of-Flight (TOF) PET scanner has been developed to measure the improvement in image quality as a function of the timing resolution. The design of the detector module is optimized for timing by coupling the 6.1×25 mm2 of 6.1×6.1×25 mm3 LSO scintillator crystals onto a 1-inch diameter Hamamatsu R-9800 PMT with super-bialkali photocathode. We characterized the imaging performance of the system. The results show that Tachyon achieved a coincidence timing re...
Source
#1Z El Bitar (UDS: University of Strasbourg)H-Index: 1
#2Ronald H. Huesman (LBNL: Lawrence Berkeley National Laboratory)H-Index: 33
Last. Grant T. Gullberg (LBNL: Lawrence Berkeley National Laboratory)H-Index: 62
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Clinical single photon emission computed tomography (SPECT) equipped with pinhole collimators have a magnification factor that results in high spatial resolution images for small animal imaging. Using Monte Carlo simulations to model the acquisition process and the propagation of the photons from their point of emission to their detection point then integrating the model into an iterative reconstruction algorithm improves the signal-to-noise ratio, the contrast and the spatial resolution in the ...
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#1Bryan W. Reutter (LBNL: Lawrence Berkeley National Laboratory)H-Index: 22
#2Ronald H. Huesman (LBNL: Lawrence Berkeley National Laboratory)H-Index: 33
Last. Grant T. GullbergH-Index: 62
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The goal of this project is to develop radionuclide molecular imaging technologies using a clinical pinhole SPECT/CT scanner to quantify changes in cardiac metabolism using the spontaneously hypertensive rat (SHR) as a model of hypertensive-related pathophysiology. This paper quantitatively compares fatty acid metabolism in hearts of SHR and Wistar-Kyoto normal rats as a function of age and thereby tracks physiological changes associated with the onset and progression of heart failure in the SHR...
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#3W.W. Moses (LBNL: Lawrence Berkeley National Laboratory)H-Index: 10
In this paper, we investigate the performance of time-of-flight (TOF) positron emission tomography (PET) in improving lesion detectability. We present a theoretical approach to compare lesion detectability of TOF versus non-TOF systems and perform computer simulations to validate the theoretical prediction. A single-ring TOF PET tomograph is simulated using SimSET software, and images are reconstructed in 2D from list-mode data using a maximum a posteriori method. We use a channelized Hotelling ...
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#4Ronald H. HuesmanH-Index: 33
#1Bryan W. Reutter (LBNL: Lawrence Berkeley National Laboratory)H-Index: 22
#2Rostyslav Boutchko (LBNL: Lawrence Berkeley National Laboratory)H-Index: 13
Last. Grant T. Gullberg (LBNL: Lawrence Berkeley National Laboratory)H-Index: 62
view all 5 authors...
The goal of this research is to quantitatively compare fatty acid metabolism in the hearts of Wistar-Kyoto (WKY) normal rats and spontaneously hypertensive rats (SHR) as a function of age, and thereby track physiological changes associated with the onset and progression of heart failure in the SHR model. The fatty acid analog, 123I-labeled BMIPP, was used in longitudinal dynamic pinhole SPECT imaging studies performed on two WKY normal rats and two SHRs every seven months for 21 months. In previ...
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#3Ronald H. HuesmanH-Index: 33
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