Physics in Medicine and Biology
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#1Yongbao Li (Sun Yat-sen University)H-Index: 11
#2Fan Xiao (SMU: Southern Medical University)
Last. Ting Song (SMU: Southern Medical University)H-Index: 7
view all 8 authors...
Objective.To develop a novel deep learning-based 3Din vivodose reconstruction framework with an electronic portal imaging device (EPID) for magnetic resonance-linear accelerators (MR-LINACs).Approach.The proposed method directly back-projected 2D portal dose into 3D patient coarse dose, which bypassed the complicated patient-to-EPID scatter estimation step used in conventional methods. A pre-trained convolutional neural network (CNN) was then employed to map the coarse dose to the final accurate...
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#1Bowen Lin (SDU: Shandong University)
#2Shujun Fu (SDU: Shandong University)H-Index: 2
Last. Hao Gao (KU: University of Kansas)H-Index: 24
view all 8 authors...
Pencil beam scanning (PBS) proton radiotherapy (RT) offers flexible proton spot placement near treatment targets for delivering tumoricidal radiation dose to tumor targets while sparing organs-at-risk (OAR). Currently the spot placement is mostly based on a non-adaptive sampling (NS) strategy on a Cartesian grid. However, the spot density or spacing during NS is a constant for the Cartesian grid that is independent of the geometry of tumor targets, and thus can be suboptimal in terms of plan qua...
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#1Devin Hymers (University of Guelph)H-Index: 1
#2Eva Kasanda (University of Guelph)H-Index: 2
Last. D. Muecher (University of Guelph)H-Index: 1
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Heavy-ion therapy, particularly using scanned (active) beam delivery, provides a precise and highly conformal dose distribution, with maximum dose deposition for each pencil beam at its endpoint (Bragg peak), and low entrance and exit dose. To take full advantage of this precision, robust range verification methods are required; these methods ensure that the Bragg peak is positioned correctly in the patient and the dose is delivered as prescribed. Relative range verification allows intra-fractio...
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#1Lu Zhao (SJTU: Shanghai Jiao Tong University)
#2Xiaowei Xu (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Jun Zhao (SJTU: Shanghai Jiao Tong University)H-Index: 32
view all 10 authors...
Objective.Subtype classification plays a guiding role in the clinical diagnosis and treatment of non-small-cell lung cancer (NSCLC). However, due to the gigapixel of whole slide images (WSIs) and the absence of definitive morphological features, most automatic subtype classification methods for NSCLC require manually delineating the regions of interest (ROIs) on WSIs.Approach.In this paper, a weakly supervised framework is proposed for accurate subtype classification while freeing pathologists f...
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#1Xianjin Dai (Emory University)H-Index: 10
#2Yang Lei (Emory University)H-Index: 22
Last. Xiaofeng Yang (Emory University)H-Index: 29
view all 9 authors...
MRI allows accurate and reliable organ delineation for many disease sites in radiation therapy due to its superior soft-tissue contrast. Manual organ-at-risk (OAR) delineation is labor-intensive, time-consuming and subjective. This study aims to develop a deep learning-based automated multi-organ segmentation method to release the labor and accelerate the treatment planning process for head-and-neck (HN) cancer radiotherapy. We propose a novel regional convolutional neural network (R-CNN) archit...
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#1Ileana Silvestre Patallo (NPL: National Physical Laboratory)H-Index: 2
#2Rebecca Carter (UCL: University College London)H-Index: 1
Last. Anna Subiel (NPL: National Physical Laboratory)H-Index: 6
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Image-guided small animal irradiation platforms deliver small radiation fields in the medium energy x-ray range. Commissioning of such platforms, followed by dosimetric verification of treatment planning, are mostly performed with radiochromic film. There is a need for independent measurement methods, traceable to primary standards, with the added advantage of immediacy in obtaining results. This investigation characterizes a small volume ionization chamber in medium energy x-rays for reference ...
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#1Fei Shi (Soochow University)H-Index: 31
#2Xuena Cheng (Soochow University)H-Index: 3
Last. Ying FanH-Index: 2
view all 11 authors...
Choroid thickness measured from optical coherence tomography (OCT) images has emerged as a vital metric in the management of retinal diseases such as high myopia. In this paper, we propose a novel group-wise context selection network (referred to as GCS-Net) to segment the choroid of either normal or high myopia eyes. To deal with the diverse choroid thickness and the variable shape of the pathological retina, GCS-Net adopts the group-wise channel dilation (GCD) module and the group-wise spatial...
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#1Shiqin Su (BCCA: BC Cancer Agency)
#2P Atwal (BCCA: BC Cancer Agency)H-Index: 4
Last. I. Antoniu Popescu (BCCA: BC Cancer Agency)H-Index: 3
view all 5 authors...
The purpose of this study is to present a novel method for generating Monte Carlo 4D dose distributions in a single DOSXYZnrc simulation. During a standard simulation, individual energy deposition events are summed up to generate a 3D dose distribution and their associated temporal information is discarded. This means that in order to determine dose distributions as a function of time, separate simulations would have to be run for each interval of interest. Consequently, it has not been clinical...
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#1Jorge Domínguez‐Kondo (BUAP: Benemérita Universidad Autónoma de Puebla)H-Index: 1
#2E. Moreno (BUAP: Benemérita Universidad Autónoma de Puebla)H-Index: 43
Last. José Ramos-Méndez (UCSF: University of California, San Francisco)H-Index: 12
view all 11 authors...
The chemical stage of the Monte Carlo track-structure code Geant4-DNA was extended for its use in DNA strand break (SB) simulations and compared against published experimental data. Geant4-DNA simulations were performed using pUC19 plasmids (2686 base pairs) in a buffered solution of DMSO irradiated by 60Co or 137Cs γ-rays. A comprehensive evaluation of SSB yields was performed considering DMSO, DNA concentration, dose and plasmid supercoiling. The latter was measured using the super helix densi...
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#1Ming Fan (HDU: Hangzhou Dianzi University)H-Index: 12
#2Wei Yuan (HDU: Hangzhou Dianzi University)H-Index: 1
Last. Lihua Li (HDU: Hangzhou Dianzi University)H-Index: 17
view all 7 authors...
Objective Breast cancer is heterogeneous in that different angiogenesis and blood flow characteristics could be present within a tumor. The pixel kinetics of DCE-MRI can assume several distinct signal patterns related to specific tissue characteristics. Identification of the latent, tissue-specific dynamic patterns of intratumor heterogeneity can shed light on the biological mechanisms underlying the heterogeneity of tumors. Approach To mine this information, we propose a deep matrix factorizati...
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