Pathology Produced by Sulfur Mustard in Human Skin Grafts on Athymic Nude Mice. II. Ultrastructural Changes

The human skin graft/nude mouse model was used to study sulfur mustard (SM) -induced pathology of skin at the ultrastructural level. The electron microscope confirms and extends the histopathology previously noted under light microscopy. SM caused extensive injury to the basal keratinocytes, the severity of which was dependent on both time and dose. Ultrastructurally visible damage took several hours to develop. The following sequence of...