Journal of Toxicology-cutaneous and Ocular Toxicology
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Papers 591
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1. This study demonstrated that the modification of calcium concentrations ([Ca2 +]) could severely affect the viability of human retinal pigment epithelial (ARPE19) cells. 2. Pharmacological agents with varying mechanisms of action: verapamil (VP), diltiazem (DIL), caffeine (CF), papaverine (PA), forskolin (FSK), ryanodine (RYN), thapsigargin (THG), and cyclosporin A (CysA) were used to evaluate the effect of modifying cytosolic Ca2 + on the viability of ARPE19 cells. The difference in cell pro...
1 CitationsSource
#1Abbass Riazi (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 2
#2Khosro Jadidi (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 3
Last. Mostafa Naderi (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 8
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Introduction: Many victims of chemical warfare (VCW) manifest some degree of refractive errors which were not present before exposure. These refractive errors are presumably long‐term (delayed) effects of sulfur mustard exposure. However, no related research studies have been done to confirm this. Myopia, hyperopia, and astigmatism are the refractive errors of the eye and prevalence of these errors depends on several factors such as hereditary factors, age, profession, and also several geographi...
1 CitationsSource
#1Ayse Oner (Erciyes University)H-Index: 22
#2Ayten Ferahbas (Erciyes University)H-Index: 12
Last. Ertugrul Mirza (Erciyes University)H-Index: 10
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Purpose. To evaluate ocular side effects associated with systemic isotretinoin. Patients and Method. Thirty‐five patients with severe recalcitrant acne were enrolled in this prospective study. Isotretinoin was administered at a dose of 0.5–1 mg/kg/day in two divided doses with food for 16 weeks. In all patients, visual acuity, anterior segment examination, intraocular pressure (IOP) measurement, Schirmer I test, tear film break‐up time (BUT), and color vision by Farnsworth‐Munsell (FM) 100 Hue c...
9 CitationsSource
#1V. Sarikaki (UoA: National and Kapodistrian University of Athens)H-Index: 1
#2Michail Rallis (UoA: National and Kapodistrian University of Athens)H-Index: 7
Last. Howard I. Maibach (UCSF: University of California, San Francisco)H-Index: 135
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One promising class of antioxidant compounds is polyphenols, contained abundantly in pine bark extract (Pycnogenol®—pine bark extract). This medicinal extract is utilized for its anti‐inflammatory properties. Its pharmacological action in skin depends on the kinetics of its absorption. In this study the dermal bioavailability of pine bark extract was investigated. Viable human skin, adapted on continuously perfused Franz cells, was applied with 5% (w/v) pine bark solution. Samples were taken at ...
14 CitationsSource
#1Michele Pauporte (UCSF: University of California, San Francisco)H-Index: 2
#2Albert J. AzzaroH-Index: 2
Last. Howard I. Maibach (UCSF: University of California, San Francisco)H-Index: 135
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The selegiline transdermal system (STS) is being developed to treat major depressive disorder. In a Phase I clinical study, the STS (20 mg/20 cm 2 ) produced mild dermal irritability and demonstrated a low potential for contact allergenicity. In Phase III multicenter studies in major depression, over 1800 patients have been evaluated for dermal safety to reveal an overall rate of application site reactions (ASRs) with STS of 21.8% compared with a placebo rate of 9.7%. Discontinuation rates due t...
5 CitationsSource
#1Cindy A. Ryan (P&G: Procter & Gamble)H-Index: 44
#2Ben C. Hulette (P&G: Procter & Gamble)H-Index: 8
Last. G. Frank Gerberick (P&G: Procter & Gamble)H-Index: 42
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The evaluation of the potential to induce allergic contact dermatitis is an important component of the overall safety assessment process of a new chemical entity that may be encountered through the skin. Currently, the murine local lymph node assay (LLNA) is the method of choice for assessing skin sensitization potential. However, despite the success of the LLNA as an alternative test method that results in a reduction in and refinement of animal usage, it does require the continued use of anima...
8 CitationsSource
#1Douglas J. Fife (UCI: University of California, Irvine)H-Index: 6
#2Howard I. Maibach (UCSF: University of California, San Francisco)H-Index: 135
Physiological differences exist between men and women that lead to different efficacy and side effect profiles of medications. Although some of this may be explained by differing pharmacodynamics, pharmacokinetic differences between the genders have been found for many medications. The oral dermatologic medications which have shown the most gender‐related differences are cyclosporine, erythromycin, and methotrexate. Cyclosporine and erythromycin are cleared faster in females, which may be due to...
5 CitationsSource
#1Chi Kong Yeung (CUHK: The Chinese University of Hong Kong)H-Index: 2
#2Sylvia W. Y. Chiang (CUHK: The Chinese University of Hong Kong)H-Index: 22
Last. Dennis S.C. Lam (CUHK: The Chinese University of Hong Kong)H-Index: 98
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Glutamate has been implicated in ocular development. The present study aims to characterize the physical changes that occur as a result of systemic intake of monosodium glutamate (MSG). As MSG has also been suggested to play a part in myopia, its effect on form‐deprived eyes was also investigated. Form‐deprivation myopia (FDM) was induced by placing a black goggle over one eye of each chick. Neonatal chicks were injected with daily MSG (0.1, 1 and 10 mg/day) or saline control for 14 days intrape...
Source
#1Leslie ClarkH-Index: 2
#2Padma BezwadaH-Index: 3
Last. T. P. O'Brien (Johns Hopkins University)H-Index: 4
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Levofloxacin, the L‐isomer of ofloxacin and a potent quinolone with a broad spectrum of antibacterial activity, was evaluated in a series of toxicology studies including acute and chronic dosing in rabbits and primates with intact and injured eyes. No evidence of ocular toxicity was observed in rabbits with intact eyes that were topically instilled with levofloxacin ophthalmic solutions under various treatment regimens, including multiple dosing (four to six times daily) for up to 26 weeks at le...
11 CitationsSource
#1Chi Kong Yeung (CUHK: The Chinese University of Hong Kong)H-Index: 2
#2Sylvia W. Y. Chiang (CUHK: The Chinese University of Hong Kong)H-Index: 22
Last. Dennis S.C. Lam (CUHK: The Chinese University of Hong Kong)H-Index: 98
view all 4 authors...
Purpose. Retinoic acid (RA) has been proposed to be of value in treating myopia, as it affects scleral growth in chicks with form‐deprivation myopia. The present study aimed to test the effects of RA injection on a form‐deprivation myopia (FDM) model in chicks. Methods. The chicks were form‐deprived by having a black goggle sutured over one eye with the contralateral eye as the control. Daily intraperitoneal injection of all‐trans RA was performed for 12 days. The eye weight (EW), ocular length ...
1 CitationsSource
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