Journal of Toxicology-cutaneous and Ocular Toxicology
Papers
598
Papers 763
1 page of 77 pages (763 results)
#1Chi Kong YeungH-Index: 2
#2Kwok Ping ChanH-Index: 13
Last. Dennis S.C. LamH-Index: 73
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1. This study demonstrated that the modification of calcium concentrations ([Ca2 +]) could severely affect the viability of human retinal pigment epithelial (ARPE19) cells. 2. Pharmacological agents with varying mechanisms of action: verapamil (VP), diltiazem (DIL), caffeine (CF), papaverine (PA), forskolin (FSK), ryanodine (RYN), thapsigargin (THG), and cyclosporin A (CysA) were used to evaluate the effect of modifying cytosolic Ca2 + on the viability of ARPE19 cells. The difference in cell pro...
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#1Abbass Riazi (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 1
#2Khosro Jadidi (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 3
Last. Mostafa Naderi (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 9
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Introduction: Many victims of chemical warfare (VCW) manifest some degree of refractive errors which were not present before exposure. These refractive errors are presumably long‐term (delayed) effects of sulfur mustard exposure. However, no related research studies have been done to confirm this. Myopia, hyperopia, and astigmatism are the refractive errors of the eye and prevalence of these errors depends on several factors such as hereditary factors, age, profession, and also several geographi...
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#1Michele Pauporte (UCSF: University of California, San Francisco)H-Index: 2
Last. Howard I. Maibach (UCSF: University of California, San Francisco)H-Index: 101
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The selegiline transdermal system (STS) is being developed to treat major depressive disorder. In a Phase I clinical study, the STS (20 mg/20 cm 2 ) produced mild dermal irritability and demonstrated a low potential for contact allergenicity. In Phase III multicenter studies in major depression, over 1800 patients have been evaluated for dermal safety to reveal an overall rate of application site reactions (ASRs) with STS of 21.8% compared with a placebo rate of 9.7%. Discontinuation rates due t...
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#1V. Sarikaki (National and Kapodistrian University of Athens)H-Index: 1
#2Michail Rallis (National and Kapodistrian University of Athens)H-Index: 8
Last. Hadi Moini (USC: University of Southern California)H-Index: 13
view all 12 authors...
One promising class of antioxidant compounds is polyphenols, contained abundantly in pine bark extract (Pycnogenol®—pine bark extract). This medicinal extract is utilized for its anti‐inflammatory properties. Its pharmacological action in skin depends on the kinetics of its absorption. In this study the dermal bioavailability of pine bark extract was investigated. Viable human skin, adapted on continuously perfused Franz cells, was applied with 5% (w/v) pine bark solution. Samples were taken at ...
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#1Cindy A. Ryan (P&G: Procter & Gamble)H-Index: 37
#2Ben C. Hulette (P&G: Procter & Gamble)H-Index: 7
Last. G. Frank Gerberick (P&G: Procter & Gamble)H-Index: 37
view all 6 authors...
The evaluation of the potential to induce allergic contact dermatitis is an important component of the overall safety assessment process of a new chemical entity that may be encountered through the skin. Currently, the murine local lymph node assay (LLNA) is the method of choice for assessing skin sensitization potential. However, despite the success of the LLNA as an alternative test method that results in a reduction in and refinement of animal usage, it does require the continued use of anima...
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#1Chi Kong Yeung (CUHK: Chinese University of Hong Kong)H-Index: 2
#2Sylvia W. Y. Chiang (CUHK: Chinese University of Hong Kong)H-Index: 14
Last. Dennis S.C. Lam (CUHK: Chinese University of Hong Kong)H-Index: 73
view all 4 authors...
Glutamate has been implicated in ocular development. The present study aims to characterize the physical changes that occur as a result of systemic intake of monosodium glutamate (MSG). As MSG has also been suggested to play a part in myopia, its effect on form‐deprived eyes was also investigated. Form‐deprivation myopia (FDM) was induced by placing a black goggle over one eye of each chick. Neonatal chicks were injected with daily MSG (0.1, 1 and 10 mg/day) or saline control for 14 days intrape...
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#1John S. GrahamH-Index: 16
#2Frances M. Reid (Battelle)H-Index: 9
Last. Jack D. Waugh (Battelle)H-Index: 2
view all 5 authors...
Background/Purpose: A weanling swine model was previously developed to study healing of cutaneous injuries induced by the blistering chemical warfare agent sulfur mustard. Noninvasive bioengineering methods are used in the model to monitor the progress of wound healing and evaluate the efficacy of treatments. It is necessary to anesthetize the animals to facilitate bioengineering data collection from ventral abdominal wound sites. As anesthetic agents affect cardiac output and deep vascular and ...
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#1Michele Pauporte (UCSF: University of California, San Francisco)H-Index: 2
Last. Howard I. Maibach (UCSF: University of California, San Francisco)H-Index: 101
view all 5 authors...
Two preclinical sensitization studies were conducted to determine the potential for allergic contact dermatitis with the selegiline transdermal system (STS), a novel transdermal system being developed to treat major depressive disorder. These included a qualitative structure‐activity relationship (QSAR) analysis to assess the allergic dermatitis potential of selegiline, and a guinea pig dermal sensitization study to determine the delayed contact hypersensitivity potential of the STS. In the QSAR...
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#1Padma BezwadaH-Index: 2
#2Leslie ClarkH-Index: 2
Last. Gregory S. Schultz (UF: University of Florida)H-Index: 61
view all 5 authors...
Levofloxacin and ofloxacin are fluoroquinolone antibacterial agents with activity against a broad spectrum of Gram‐positive and Gram‐negative ocular pathogens. Levofloxacin is the pure S‐(−) isomer of ofloxacin, and is approximately twice as active as the R‐(+) isomer. Studies were conducted to measure the pharmacokinetics of levofloxacin and ofloxacin in the cornea and aqueous humor of the intact rabbit eye and also to determine the therapeutic efficacy of the two compounds for the treatment of...
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#1Paul I. Dantzig (CU: Columbia University)H-Index: 4
Mercury poisoning is becoming a health concern due to the extensive pollution of water and fish and the increasing consumption of fish in the human diet. Mercury is extremely toxic to the body, especially the central nervous system, but diagnosis is difficult due to the lack of specific signs. We report four patients with persistent palmar plaques that correlated with blood mercury levels and cleared upon the elimination of mercury from the body.
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