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doi.org/10.1073/pnas.1413282112

Allosteric activation of ADAMTS13 by von Willebrand factor

..., J. Evan Sadler
48
Proceedings of the National Academy of Sciences of the United States of America11.10
Volume: 111, Issue: 52, Pages: 18584 - 18589
Published: Dec 15, 2014
Abstract
The metalloprotease ADAMTS13 cleaves von Willebrand factor (VWF) within endovascular platelet aggregates, and ADAMTS13 deficiency causes fatal microvascular thrombosis. The proximal metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains of ADAMTS13 recognize a cryptic site in VWF that is exposed by tensile force. Another seven T and two complement C1r/C1s, sea urchin epidermal growth factor, and...
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Paper Details
Title
Allosteric activation of ADAMTS13 by von Willebrand factor
DOI
doi.org/10.1073/pnas.1413282112
Published Date
Dec 15, 2014
Journal
Proceedings of the National Academy of Sciences of the United States of America
Volume
111
Issue
52
Pages
18584 - 18589
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