Absence of Histological Changes after the Administration of a Continuous Intrathecal Clonidine in Wistar rats

The administration of epidural and spinal clonidine has demonstrated an antinociceptive effect in animals and humans. For that reason, its spinal administration has been proposed as an adjuvant in chronic pain management. However, there is limited information about its possible neurotoxic effect after its continuous neuraxial administration.Twelve male Wistar rats were randomly divided into two groups. Using an osmotic mini-pump a continuous...