Absence of Histological Changes after the Administration of a Continuous Intrathecal Clonidine in Wistar rats

Published on Mar 1, 2009in Pain Practice2.258
· DOI :10.1111/J.1533-2500.2008.00251.X
Uriah Guevara-López11
Estimated H-index: 11
(Mexican Social Security Institute),
J. Antonio Aldrete3
Estimated H-index: 3
(UAB: University of Alabama at Birmingham)
+ 2 AuthorsFrancisco Javier López-Muñoz26
Estimated H-index: 26
(CINVESTAV)
Sources
Abstract
Background: The administration of epidural and spinal clonidine has demonstrated an antinociceptive effect in animals and humans. For that reason, its spinal administration has been proposed as an adjuvant in chronic pain management. However, there is limited information about its possible neurotoxic effect after its continuous neuraxial administration.
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