Gene Profile Highlights Late Rectal Bleeding Protection in Prostate Cancer 3D Conformal Radiation

Purpose/Objective(s)Despite 3-D CRT, 5–10% patients (pts) treated for prostate cancer can still suffer from significant morbidity (tox). Based on recent findings where abnormal transcriptional responses to DNA damage were associated to acute tox, to identify markers predicting late rectal bleeding (lrb), we analysed 35 genes involved in DNA-repair or pathways known as targets for RT. Pts were selected within the AIROPROS 0101 trial, designed to...