Icariin induces osteogenic differentiation of bone mesenchymal stem cells in a MAPK‐dependent manner

Objectives Icariin, a flavonoid isolated from Epimedium pubescens , has previously been identified to exert beneficial effects on preventing bone loss and promoting bone regeneration. However, molecular mechanisms for its anabolic action have, up to now, remained largely unknown. Materials and methods Effects of icariin on cell proliferation and osteogenic differentiation of rat bone mesenchymal stem cells ( BMSC s) were systematically...