Yuqiong Wu
Shanghai Jiao Tong University
OsteocalcinEndocrinologyVascular endothelial growth factor ACellular differentiationKinaseMaterials scienceMesenchymal stem cellOsteoclastRANKLAngiogenesisIcariinMTT assayBone regenerationp38 mitogen-activated protein kinasesMAPK/ERK pathwaySignal transductionProtein kinase BOvariectomized ratCell biologyProtein kinase A
5Publications
5H-index
180Citations
Publications 5
Newest
#1Yuqiong Wu (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Lingyan Cao (SJTU: Shanghai Jiao Tong University)H-Index: 9
Last. Xinquan Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 52
view all 10 authors...
Typically, bone regenerative medicine is applied to repair bone defects in patients with osteoporosis. Meanwhile, there is an urgent need to develop safe and cheap drugs that induce bone formation. Icariin, which is reported to promote the osteogenesis of stem cells in vitro, is the main active component of Herba Epimedii. However, whether icariin could repair bone defects caused by osteoporosis remains unknown. In this study, an osteoporosis model in rats was established by an ovariectomy first...
27 CitationsSource
#1Yuning Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Yuqiong Wu (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. Yuanjin Xu (SJTU: Shanghai Jiao Tong University)H-Index: 12
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Bone regeneration under osteoporotic conditions with impaired angiogenesis, osteogenesis and remodeling represents a great challenge. In the present study, the effects of quercetin on proliferation, osteogenic differentiation and angiogenic factor secretion as well as on the osteoclastogenic factor secretion of ovariectomized (OVX) rat bone marrow-derived mesenchymal stem cells (rBMSCs) were first evaluated in vitro. The role of mitogen-activated protein kinase (MAPK) signaling pathways and the ...
12 CitationsSource
#1Yuqiong Wu (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Lunguo Xia (SJTU: Shanghai Jiao Tong University)H-Index: 29
Last. Xinquan Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 52
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Icariin has been identified to promote osteogenic differentiation of bone mesenchymal stem cells (BMSCs). However, whether icariin could enhance angiogenic factor expression of BMSCs, which may be vital for bone repair, needs to be explored. Moreover, how to construct a delivery system of icariin and its repair capability in bone defects are still unknown. In the present study, the effects of icariin on the osteogenic differentiation and angiogenic factor expression of BMSCs were firstly evaluat...
18 CitationsSource
#1Yuning Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Yuqiong Wu (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. Yuanjin Xu (SJTU: Shanghai Jiao Tong University)H-Index: 12
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Bone marrow-derived mesenchymal stem cells (BMSCs) are widely used in regenerative medicine in light of their ability to differentiate along the chondrogenic and osteogenic lineages. As a type of traditional Chinese medicine, quercetin has been preliminarily reported to promote osteogenic differentiation in osteoblasts. In the present study, the effects of quercetin on the proliferation, viability, cellular morphology, osteogenic differentiation and angiogenic factor secretion of rat BMSCs (rBMS...
56 CitationsSource
#1Yuqiong Wu (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Lunguo Xia (SJTU: Shanghai Jiao Tong University)H-Index: 29
Last. Xinquan Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 52
view all 5 authors...
Objectives Icariin, a flavonoid isolated from Epimedium pubescens, has previously been identified to exert beneficial effects on preventing bone loss and promoting bone regeneration. However, molecular mechanisms for its anabolic action have, up to now, remained largely unknown. Materials and methods Effects of icariin on cell proliferation and osteogenic differentiation of rat bone mesenchymal stem cells (BMSCs) were systematically evaluated. To characterize underlying mechanisms, its effects o...
65 CitationsSource