Cell Proliferation
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#1Yihuan Mao (CAS: Chinese Academy of Sciences)H-Index: 3
#2Libin Wang (CAS: Chinese Academy of Sciences)H-Index: 9
Last. Qi ZhouH-Index: 81
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Objectives null Derivation and maintenance of pluripotent stem cells (PSCs) generally require optimized and complex culture media, which hinders the derivation of PSCs from various species. Expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) can reprogram somatic cells into induced PSCs (iPSCs), even for species possessing no optimal culture condition. Herein, we explored whether expression of OSKM could induce and maintain pluripotency without PSC-specific growth factors and signaling inhibitors. ...
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#1Lvwan Xu (ZJU: Zhejiang University)H-Index: 1
#2Xin Ye (ZJU: Zhejiang University)
Last. Lin-Lin Wang (ZJU: Zhejiang University)H-Index: 16
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T cells participate in the repair process and immune response in the CNS post-traumatic injury and play both a beneficial and harmful role. Together with nerve cells and other immune cells, they form a microenvironment in the CNS post-traumatic injury. The repair of traumatic CNS injury is a long-term process. T cells contribute to the repair of the injury site to influence the recovery. Recently, with the advance of new techniques, such as mass spectrometry-based flow cytometry, modern live-cel...
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#1Te Liu (SHU: Shanghai University)
#2Fangyuan Jing (SHU: Shanghai University)
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Objective null Thymopentin (5TP) significantly improved typical murine premature ovarian failure (POF) symptoms induced by a high-fat and high-sugar (HFHS) diet. However, its effect and mechanism remain unclear. null Materials and methods null RNA-Seq was used to detect the differentially expressed genes among each group. HFHS-induced POF mouse model was generated and injected with siRNA using Poly (lactic-co-glycolic acid) (PLGA) as a carrier. null Results null RNA-Seq suggested that 5TP promot...
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#1Xuyang Liu (Sichuan University)H-Index: 2
Last. Yanjing Li (Sichuan University)H-Index: 6
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OBJECTIVES Autoimmune diseases are a heterogeneous group of diseases which lose the immunological tolerance to self-antigens. It is well recognized that irregularly provoked T cells participate in the pathological immune responses. As a novel nanomaterial with promising applications, tetrahedral framework nucleic acid (TFNA) nanostructure was found to have immune regulatory effects on T cells in this study. MATERIALS AND METHODS To verify the successful fabrication of TFNA, the morphology of TFN...
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#1Lingjuan Wang (HUST: Huazhong University of Science and Technology)
#2Weina Yang (HUST: Huazhong University of Science and Technology)H-Index: 2
Last. Fengli Wang (HUST: Huazhong University of Science and Technology)H-Index: 1
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It is indispensable for cells to adapt and respond to environmental stresses, in order for organisms to survive. Stress granules (SGs) are condensed membrane-less organelles dynamically formed in the cytoplasm of eukaryotes cells to cope with diverse intracellular or extracellular stress factors, with features of liquid-liquid phase separation. They are composed of multiple constituents, including translationally stalled mRNAs, translation initiation factors, RNA-binding proteins and also non-RN...
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#1Bo-Ram Jin (Sangji University)H-Index: 6
#2Minho Lee (Dongguk University)H-Index: 13
Last. Hyo-Jin An (Sangji University)H-Index: 20
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OBJECTIVES Nodakenin (NK) is a coumarin glucoside that is found in the roots of Angelicae gigas. A limited number of studies have been conducted on the pharmacological activities of NK. Although NK is an important natural resource having anti-inflammatory and antioxidant effects, no investigation has been conducted to examine the effects of NK on obesity and obesity-induced inflammation. MATERIALS AND METHODS The present study investigated the therapeutic effects of NK treatment on obesity and i...
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#1Liying Wang (CAS: Chinese Academy of Sciences)H-Index: 2
#2Zhiliang Xu (Guangzhou Medical University)
Last. Sai Xiao (CAS: Chinese Academy of Sciences)H-Index: 2
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Objectives null Cell reprogramming has significant impacts on their potential application in regenerative medicine. Chromatin remodelling plays a very important role in cell reprogramming, but its underlying mechanism remains poorly understood. null Materials and methods null RNA-seq, quantitative RT-PCR and western blot analysis were applied to study the role of RNF20 and H2B ubiquitination during mouse somatic cell reprogramming. Chromatin structure and the recruitment of transcription factors...
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#1Hyun-Jung ParkH-Index: 9
Last. Jihwan SongH-Index: 25
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OBJECTIVES To investigate whether human HLA-homozygous induced pluripotent stem cell (iPSC)-derived neural precursor cells (iPSC-NPCs) can provide functional benefits in Huntington's disease (HD), we transplanted them into the YAC128 transgenic HD mouse model. MATERIALS AND METHODS CHAi001-A, an HLA-homozygous iPSC line (A*33:03-B*44:03-DRB1*13:02), was differentiated into neural precursor cells, and then, they were transplanted into 6 months-old YAC128 mice. Various behavioural and histological...
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#1Hongyao Liu (Sichuan University)H-Index: 3
#2Xiuli Wu (Sichuan University)H-Index: 3
Last. Qianyu Zhang (Sichuan University)H-Index: 3
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Objectives null Idiopathic pulmonary fibrosis (IPF) is marked by the excessive accumulation of extracellular matrix, which participates in a variety of chronic diseases or injuries and seriously threatens human health. Due to the side effects of clinical drugs, there is still a need to develop novel and less toxic drugs to treat pulmonary fibrosis. null Materials and methods null SKLB-YTH-60 was developed through computer-aided drug design, de novo synthesis and high-throughput screening. We emp...
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#1Yu Li (ZJU: Zhejiang University)H-Index: 5
#2Bingbing Wu (ZJU: Zhejiang University)H-Index: 6
Last. Xiaohui Zou (ZJU: Zhejiang University)H-Index: 19
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Objective null The loss of LOXL1 expression reportedly leads to the prolapse of pelvic organs or to exfoliation syndrome glaucoma. Increasing evidence suggests that LOXL1 deficiency is associated with the pathogenesis of several other diseases. However, the characterization of the systemic functions of LOXL1 is limited by the lack of relevant investigative technologies. null Materials and methods null To determine the functions of LOXL1, a novel method for body-wide organ transcriptome profiling...
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