Cell Proliferation
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#1Jie Mei (CSU: Central South University)
#2Huixiang Tian (CSU: Central South University)
Last. Tang-Yuan ChuH-Index: 25
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High-grade serous carcinoma (HGSC) is the most common and malignant histological type of epithelial ovarian cancer, the origin of which remains controversial. Currently, the secretory epithelial cells of the fallopian tube are regarded as the main origin and the ovarian surface epithelial cells as a minor origin. In tubal epithelium, these cells acquire TP53 mutations and expand to a morphologically normal 'p53 signature' lesion, transform to serous tubal intraepithelial carcinoma and metastasiz...
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#1Yangyang Cao (Capital Medical University)H-Index: 7
#2Le Li (THU: Tsinghua University)
Last. Zhipeng Fan (Capital Medical University)
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The stem cells differentiate into osteoblasts or neurocytes is the key process for treatment of bone- or neural tissue-related diseases which is caused by ageing, fracture, injury, inflammation, etc Polycomb group complexes (PcGs), especially the polycomb repressive complex 2 (PRC2), act as pivotal epigenetic regulators by modifying key developmental regulatory genes during stem cells differentiation. In this review, we summarize the core subunits, the variants and the potential functions of PRC...
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#1Yinan Li (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Xiangjiang Guo (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. Lan Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 8
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Background Vascular smooth muscle cells (VSMC) switch to macrophage-like cells after cholesterol loading, and this change may play an important role in atherogenesis. Muscleblind-like splicing regulator 1 (MBNL1) is a well-known splicing factor that has been implicated in many cellular processes. However, the role of MBNL1 in VSMC macrophage-like transdifferentiation is largely unknown. In this study, we aim to characterize the role of MBNL1-induced gene splicing during atherogenesis. Methods Th...
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#1Huan Zhou (Fourth Military Medical University)H-Index: 1
#2Xuan Li (Fourth Military Medical University)H-Index: 9
Last. Fa-Ming Chen (Fourth Military Medical University)H-Index: 27
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Objectives Previously, our investigations demonstrated robust pro-angiogenic potentials of extracellular vesicles secreted by periodontitis-compromised dental pulp stem cells (P-EVs) when compared to those from healthy DPSCs (H-EVs), but the underlying mechanism remains unknown. Materials and methods Here, circulating microRNAs (miRNAs) specifically found in P-EVs (compared with H-EVs) were identified by Agilent miRNA microarray analysis, and the roles of the candidate miRNA in P-EV-enhanced cel...
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#1Neng Tang (NU: Nanjing University)H-Index: 1
#2Shanshan Xu (NU: Nanjing University)
Last. Xiao Fu (NU: Nanjing University)H-Index: 2
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#1Wensi Liu (PRC: China Medical University (PRC))H-Index: 2
#2Haichao Tang (PRC: China Medical University (PRC))H-Index: 2
Last. Jianping Li (PRC: China Medical University (PRC))
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#1Yanping XuH-Index: 4
#2Jiaqi ZhuH-Index: 3
Last. Hongcui CaoH-Index: 26
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OBJECTIVES Acute lung injury (ALI) not only affects pulmonary function but also leads to intestinal dysfunction, which in turn contributes to ALI. Mesenchymal stem cell (MSC) transplantation can be a potential strategy in the treatment of ALI. However, the mechanisms of synergistic regulatory effects by MSCs on the lung and intestine in ALI need more in-depth study. MATERIALS AND METHODS We evaluated the therapeutic effects of MSCs on the murine model of lipopolysaccharide (LPS)-induced ALI thro...
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#1Bowen Zhang (Sichuan University)
#2Xin Qin (Sichuan University)H-Index: 5
Last. Xiaoxiao Cai (Sichuan University)H-Index: 24
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OBJECTIVES Anti-microbial peptides (AMPs) have been comprehensively investigated as a novel alternative to traditional antibiotics against microorganisms. Meanwhile, Tetrahedral DNA nanostructures (TDNs) have gained attention in the field of biomedicine for their premium biological effects and transportation efficiency as delivery vehicles. Hence, in this study, TDN/Histatin 5 (His-5) was synthesized and the transport efficiency and anti-fungal effect were measured to evaluate the promotion of H...
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#1Zha Kangkang (NKU: Nankai University)H-Index: 1
#2Xu Li (CUHK: The Chinese University of Hong Kong)H-Index: 3
Last. Quanyi Guo (NKU: Nankai University)H-Index: 2
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Objectives CD49f is expressed on a variety of stem cells and has certain effects on their cytological functions, such as proliferation and differentiation potential. However, whether CD49f is expressed on the surface of adipose tissue-derived mesenchymal stem cells (ADSCs) and its effect on ADSCs has not been clarified. Materials and methods The effects of in vitro culture passage and inflammatory factor treatment on CD49f expression and the adhesion ability of ADSCs from mice and rats were inve...
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#1Chenxia Hu (ZJU: Zhejiang University)H-Index: 11
#2Lingfei Zhao (ZJU: Zhejiang University)H-Index: 7
Last. Lanjuan Li (ZJU: Zhejiang University)H-Index: 72
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Although the liver is the only organ with regenerative capacity, various injury factors induce irreversible liver dysfunction and end-stage liver disease. Liver resection and liver transplantation (LT) are effective treatments for individuals with liver failure, liver cirrhosis and liver cancers. The remnant or transplanted liver tissues will undergo hepatic ischaemia/reperfusion (IR), which leads to oxidative stress, inflammation, immune injury and liver damage. Moreover, systemic ischaemia ind...
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