Targeting Platelet–Leukocyte Interactions
Volume: 198, Issue: 7, Pages: 1077 - 1088
Published: Oct 6, 2003
Abstract
The firm adhesion and transplatelet migration of leukocytes on vascular thrombus are dependent on the interaction of the leukocyte integrin Mac-1 (alphaMbeta2, CD11b/CD18) and the platelet counter receptor glycoprotein (GP) Ibalpha. Previous studies have established a central role for the I domain, a stretch of approximately 200 amino acids within the alphaM subunit, in the binding of GP Ibalpha. This study was undertaken to establish the...
Paper Details
Title
Targeting Platelet–Leukocyte Interactions
Published Date
Oct 6, 2003
Volume
198
Issue
7
Pages
1077 - 1088
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