Retinopathy of prematurity in Korean infants with birthweight greater than 1500 g

Published on Jun 1, 2016in British Journal of Ophthalmology3.611
· DOI :10.1136/BJOPHTHALMOL-2015-306960
Shin Hae Park9
Estimated H-index: 9
(Catholic University of Korea),
Hae Ri Yum3
Estimated H-index: 3
(Konyang University)
+ 1 AuthorsYoung Chun Lee11
Estimated H-index: 11
(Catholic University of Korea)
Objective To determine the incidence and clinical features of, and risk factors for, retinopathy of prematurity (ROP) in Korean infants with birthweight (BW) >1500 g. Methods A total of 201 consecutive infants with BW >1500 g from January 2009 to December 2013 were included. The location and maximal stage of retinopathy observed were recorded for each infant. The associated systemic and maternal risk factors in infants with mild or absent ROP were compared with those in infants with treatment-requiring ROP. Results The total incidence of ROP was 11.94% and that of treatment-requiring ROP was 3.98%. Two patients with gestational age (GA) >32 weeks and BW >1500 g had treatment-requiring ROP. 15 eyes from eight infants with type I ROP required laser photocoagulation. The mean BWs and GAs in the treatment-requiring ROP group were significantly lower than those in the no or mild ROP group. Total duration of oxygen supplementation, surfactant usage, respiratory distress syndrome, bronchopulmonary dysplasia, antibiotic use for more than 14 days and the number of ROP-associated risk factors significantly increased the likelihood of treatment-requiring ROP (p=0.002, p=0.008, p=0.008, p=0.000, p=0.015, and p=0.004, respectively). Conclusion Our study confirmed that treatment-requiring ROP does occur in infants with BW >1500 g. To avoid overlooking infants with vision-threatening ROP, an evaluation of the data from larger BW preterm infants is advisable so that screening guidelines in neonatal care units may be refined.
📖 Papers frequently viewed together
164 Citations
29 Citations
1 Author (Eva Maly)
17 Citations
#1Tanveer Anjum Chaudhry (Aga Khan University)H-Index: 7
#2Farzeen Khalid Hashmi (Aga Khan University)H-Index: 2
Last. Khabir Ahmad (Aga Khan University)H-Index: 19
view all 8 authors...
Aim To evaluate if broadening the criteria for retinopathy of prematurity (ROP) screening to include babies with gestational age ≥32 weeks and/or birth weight ≥1500 g, would have an impact on the number of babies diagnosed as having ROP. Methods A prospective cohort study was carried out at the Aga Khan University Hospital, Karachi, Pakistan. Infants with gestational age ≤35 weeks or birth weight ≤2000 g born in this hospital from May 2010 to December 2012 were screened for the presence of ROP 4...
6 CitationsSource
#1Gaurav SanghiH-Index: 8
#2Mangat R DograH-Index: 23
Last. Amod GuptaH-Index: 57
view all 4 authors...
In this retrospective case series, we report the spectrum and outcomes of aggressive posterior retinopathy of prematurity (APROP) in infants ≥1500 g birth weight. Twenty-nine eyes of 15 infants are included. All infants were referred from level I or II nurseries, received supplemental unmonitored oxygen for prolonged duration (>1 week) and had multiple systemic co-morbidities. Of the 29 eyes, 10 (34.5%) had zone 1 and 19 (65.5%) had posterior zone 2 disease. Twenty-five (86.2%) eyes had flat neo...
21 CitationsSource
#1Yu Xu (SJTU: Shanghai Jiao Tong University)H-Index: 12
#2Xiaohong Zhou (Fudan University)H-Index: 1
Last. Peiquan Zhao (SJTU: Shanghai Jiao Tong University)H-Index: 21
view all 8 authors...
Abstract To analyze the incidence and severity of retinopathy of prematurity (ROP) in China, and to explore the workload implications of applying different criteria. A prospective, neonatal units-based study undertaken in two tertiary level hospitals in Shanghai, China, from January 1, 2010 to December 31, 2012. All infants with birth weight (BW) of 2000 g or less and/or gestational age (GA) of 34 weeks or less were screened for ROP. Retinopathy of prematurity was classified using the internatio...
41 CitationsSource
#1Yi-Hsing Chen (CGU: Chang Gung University)H-Index: 8
#2Reyin Lien (CGU: Chang Gung University)H-Index: 24
Last. Wei-Chi Wu (CGU: Chang Gung University)H-Index: 27
view all 11 authors...
Background: To understand the characteristics, ophthalmic outcomes, and risk factors of retinopathy of prematurity (ROP) in patients with birth weight (BW) greater than 1500 g. The applicability of the ROP screening criteria to the Taiwanese population was also examined. Methods: The study included 104 eyes from 54 ROP patients who had BW greater than 1500 g from 1981 to 2008. Demographic information, disease courses, ophthalmic outcomes, and possible systemic risk factors were recorded. The inf...
10 CitationsSource
#1Jung-Han Choi (Chonnam National University)H-Index: 1
#2Chatarina LöfqvistH-Index: 30
Last. Hwan HeoH-Index: 1
view all 4 authors...
Objective To investigate the efficacy of WINROP (, an algorithm based on serial measurements of neonatal body weight to predict proliferative retinopathy of prematurity (ROP), in a Korean population of preterm infants. Methods The records of preterm infants with gestational age less than 32 weeks who were admitted to the neonatal intensive care unit at Chonnam National University Hospital, Gwangju, South Korea, from October 2006 to November 2010 were reviewed. The body weight ...
31 CitationsSource
#1Mingui Kong (SMC: Samsung Medical Center)H-Index: 5
#2Dong Hoon Shin (SMC: Samsung Medical Center)H-Index: 4
Last. Won Soon Park (SMC: Samsung Medical Center)H-Index: 42
view all 7 authors...
As younger preterm infants are able to survive, more extremely preterm infants are at risk of developing retinopathy of prematurity (ROP). To investigate the incidence, progression and risk factors of ROP in extremely preterm infants in Korea, the medical records of infants born before 25 weeks gestation were retrospectively reviewed. The criteria for laser treatment agreed with type 1 ROP as defined by the Early Treatment for Retinopathy of Prematurity study. Of the 121 infants included in the ...
13 CitationsSource
Aims To evaluate incidence of retinopathy of prematurity (ROP) and validity of current ROP screening criteria adopted in the Armed Forces Hospitals. Methods A retrospective study of ROP indices was carried out in infants admitted to the neonatal intensive care unit in Khamis Mushait, Saudi Arabia, from January 2009 to December 2011. All infants who had birth weight (BW) of 1500 g or less and/or gestational age (GA) of 32 weeks or less had their data reviewed for ROP diagnosis and related indices...
16 CitationsSource
#1Mei-Hong Gu (ZJU: Zhejiang University)H-Index: 1
#2Ji Jin (ZJU: Zhejiang University)H-Index: 1
Last. Hui-Min YuH-Index: 1
view all 4 authors...
Objective: To determine the risk factors and outcomes of retinopathy of prematurity (ROP) in infants with a birth weight of 1,501–2,000 g. Materials and Methods: Clinical characteristics and risk factors were compared and nonconditional logistic regression analysis was performed to determine independent predictors for ROP. Results: There were 54 (9.8%) cases of ROP in 553 patients with a birth weight of 1,501–2,000 g. The most common classification of ROP was in stage 1 (50/54, 92.6%; stages 2 a...
8 CitationsSource
Objective To assess the risk of severe retinopathy of prematurity (ROP) requiring treatment in different ethnic groups. Design Retrospective observational study on ROP screening and treatment. It involved a cross-sectional review of all eligible infants over a seven-year period. Statistical tests used were the Kruskal-Wallis test and Mann-Whitney U test. Logistic regression was used to control for any differences in birth weight and gestational age. Setting City Hospital and Birmingham Women9s H...
33 CitationsSource
#1M Al-Essa (Kuniv: Kuwait University)H-Index: 1
#2N RashwanH-Index: 1
Last. M Al-AjmiH-Index: 1
view all 3 authors...
Objective : To identify the rate and prognosis of retinopathy of prematurity (ROP) among newborn infants of birthweight of above 1500 grams, and the possible risk factors associated with the disease. Design : A prospective cohort study. Setting : Neonatal unit at Maternity Hospital, Kuwait city, Kuwait. Methods : All low birth weight infants were examined for the presence of ROP in the period between January 1996 to December 1997. Prospective collection of data on babies who were above 1500 gram...
3 CitationsSource
Cited By9
#4Alexandra ScrivensH-Index: 1
AIM This study aims to determine the incidence of ROP and to investigate its prognosis among premature babies with a BW of ≥2000 g. MATERIAL AND METHOD We retrospectively analyzed the data of 1004 babies with BW≥2000 g admitted to the ROP Diagnosis and Treatment Centers of X University Hospital and X Hospital between 2018 and 2019. Examination findings were recorded according to the Classification of Retinopathy of Prematurity guideline. We recorded the following information: GA, BW, type of del...
#1Sang Jin Kim (OHSU: Oregon Health & Science University)H-Index: 6
#4Kemal Sonmez (OHSU: Oregon Health & Science University)H-Index: 18
Last. Michael F. Chiang (OHSU: Oregon Health & Science University)H-Index: 47
view all 16 authors...
Retinopathy of prematurity (ROP) is a vasoproliferative retinal disease affecting premature infants. In addition to prematurity itself and oxygen treatment, genetic factors have been suggested to predispose to ROP. We aimed to identify potentially pathogenic genes and biological pathways associated with ROP by analyzing variants from whole exome sequencing (WES) data of premature infants. As part of a multicenter ROP cohort study, 100 non-Hispanic Caucasian preterm infants enriched in phenotypic...
#1Eun Hee Hong (Hanyang University)H-Index: 5
#2Yong Un Shin (Hanyang University)H-Index: 11
Last. Heeyoon Cho (Hanyang University)H-Index: 9
view all 9 authors...
The aim of this study is to investigate the nationwide incidence and treatment pattern of retinopathy of prematurity (ROP) in South Korea. Using the population-based National Health Insurance database (2007-2018), the nationwide incidence of ROP among premature infants with a gestational age (GA) < 37 weeks (GA < 28 weeks, GA28; 28 weeks ≤ GA < 37 weeks; GA28-37) and the percentage of ROP infants who underwent treatment [surgery (vitrectomy, encircling/buckling); retinal ablation (laser photocoa...
1 CitationsSource
#1Lara S. Carroll (UofU: University of Utah)H-Index: 8
#2Leah A. Owen (UofU: University of Utah)H-Index: 13
: Retinopathy of prematurity (ROP) is a blinding morbidity of preterm infants, which represents a significant clinical problem, accounting for up to 40% of all childhood blindness. ROP displays a range of severity, though even mild disease may result in life-long visual impairment. This is complicated by the fact that our current treatments have significant ocular and potentially systemic effects. Therefore, disease prevention is desperately needed to mitigate the life-long deleterious effects o...
3 CitationsSource
#1Eduardo Villamor-Martinez (UM: Maastricht University)H-Index: 8
#2Giacomo Cavallaro (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 17
Last. Eduardo Villamor (UM: Maastricht University)H-Index: 64
view all 9 authors...
The role of chorioamnionitis (CA) in the development of retinopathy of prematurity (ROP) is difficult to establish, because CA-exposed and CA-unexposed infants frequently present different baseline characteristics. We performed an updated systematic review and meta-analysis of studies reporting on the association between CA and ROP. We searched PubMed and EMBASE for relevant articles. Studies were included if they examined preterm or very low birth weight (VLBW, <1500g) infants and reported prim...
16 CitationsSource
#1Sang Jin Kim (OHSU: Oregon Health & Science University)H-Index: 6
#2Alexander D. Port (Cornell University)H-Index: 7
Last. Michael F. Chiang (OHSU: Oregon Health & Science University)H-Index: 47
view all 6 authors...
Abstract Retinopathy of prematurity (ROP) is a retinal vasoproliferative disease that affects premature infants. Despite improvements in neonatal care and management guidelines, ROP remains a leading cause of childhood blindness worldwide. Current screening guidelines are primarily based on two risk factors: birth weight and gestational age; however, many investigators have suggested other risk factors, including maternal factors, prenatal and perinatal factors, demographics, medical interventio...
84 CitationsSource
#1Ye Jin Ahn (Catholic University of Korea)H-Index: 3
#2K E Hong (Catholic University of Korea)H-Index: 1
Last. Shin Hae Park (Catholic University of Korea)H-Index: 9
view all 7 authors...
To identify the risk factors for, and clinical features and treatment outcomes of aggressive posterior retinopathy of prematurity (APROP) in Korean infants. Among 770 premature infants who underwent screening, 105 infants (198 eyes, 13.63%) received treatment for ROP. A total of 24 infants (48 eyes, 3.12%) developed APROP while 81 infants (150 eyes, 10.52%) developed non-APROP treatment-requiring type. The medical records of ROP-treated infants were reviewed retrospectively. The associated syste...
15 CitationsSource