Cortistatin Inhibits Growth Hormone Release from Human Fetal and Adenoma Pituitary Cells and Prolactin Secretion from Cultured Prolactinomas

Cortistatin (CST) is a neuropeptide that shares high homology with somatostatin and binds with high affinity to all somatostatin receptor (SSTR) subtypes. Many of its endocrine and biological activities overlap with those of somatostatin.The objective of the study was to assess the direct in vitro effects of CST on human pituitary hormone secretion.This study was performed in the endocrine laboratory of a tertiary academic medical center.Primary...