Biology and physics of von Willebrand factor concatamers
Abstract
Structural specialisations enable von Willebrand factor (VWF) to assemble during biosynthesis into helical tubules in Weibel-Palade bodies (WPB). Specialisations include a pH-regulated dimeric bouquet formed by the C-terminal half of VWF and helical assembly guided by the N-terminal half that templates inter-dimer disulphide bridges. Orderly assembly and storage of ultra-long concatamers in helical tubules, without crosslinking of neighboring...
Paper Details
Title
Biology and physics of von Willebrand factor concatamers
Published Date
Jul 1, 2011
Volume
9
Pages
130 - 143
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