Course of Platelet Activation Markers After Ischemic Stroke

Published on Nov 1, 2002in Stroke7.19
· DOI :10.1161/01.STR.0000034398.34938.20
Lars Marquardt3
Estimated H-index: 3
(Heidelberg University),
Andreas Ruf17
Estimated H-index: 17
+ 5 AuthorsArmin J. Grau47
Estimated H-index: 47
Background and Purpose— The aim of this study was to evaluate the time course of platelet activation after ischemic stroke and to investigate whether platelet activation and inflammation are correlated with each other. Methods— We serially determined expression of p-selectin (CD62p) and lysosome-associated membrane protein (CD63) by platelets using flow cytometry at 10 time points between days 1 and 90 in patients after ischemic stroke (n=50), in healthy subjects (n=30), and in risk factor control subjects (n=20). Furthermore, we correlated leukocyte count, C-reactive protein, and fibrinogen levels with platelet activation markers. Results— CD62p and CD63 expression was higher on day 1 after stroke than in both control groups (P<0.005 for both). CD62p expression rapidly declined, whereas CD63 expression remained significantly elevated until day 90. Stroke severity and different medication for secondary stroke prevention did not influence CD62p or CD63 expression. Platelet activation markers and inflammato...
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