Andreas Ruf
Heidelberg University
Internal medicineEndocrinologyPathologyCardiologyChemistryImmunologyPlatelet membrane glycoproteinGlycoprotein IIb/IIIaFibrinolysisThrombinVascular diseaseAspirinAbciximabCoagulationFibrinogenThrombosisThromboxane A2Platelet activationFibrinogen bindingStrokeIschemiaBiochemistryMedicinePlatelet
Publications 23
#1Lars MarquardtH-Index: 3
#2Andreas RufH-Index: 17
Last. Armin J. GrauH-Index: 47
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Abstract Background and purpose This study aimed to characterize the time course of inflammatory parameters after acute ischemic stroke. Methods We serially determined high sensitivity C-reactive protein (CRP), fibrinogen, and leukocyte counts at 10 time points between days 1 and 90 after ischemic stroke and in control subjects. Results CRP did not significantly change, whereas fibrinogen increased after stroke. At all time points, CRP and fibrinogen were higher than in healthy control subjects,...
43 CitationsSource
#1Ulrich J. SachsH-Index: 33
Last. Sentot SantosoH-Index: 56
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The CD11b/CD18 integrin plays a crucial role in cell-cell adhesion processes. Recently, we described a case of severe neonatal alloimmune neutropenia (NAIN) caused by an alloantibody against a variant of the CD11b subunit (Mart alloantigen). Allele-specific transfected cells allowed us to demonstrate that an H61R point mutation is directly responsible for the formation of Mart epitopes. No difference in the adhesion capability between H61 and R61 homozygous neutrophils was observed. Functional a...
43 CitationsSource
#1Armin J. Grau (Heidelberg University)H-Index: 47
#2Sven Reiners (Heidelberg University)H-Index: 1
Last. Andreas Ruf (Heidelberg University)H-Index: 17
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Background and Purpose— Combined antiplatelet agents may offer additive protection over single drugs after stroke. We investigated whether platelet activation is reduced under combined aspirin and clopidogrel compared with each drug alone. Methods— In a case-crossover study, 31 patients with previous atherothrombotic or lacunar stroke who were treated with aspirin (100 to 300 mg/d) received clopidogrel (75 mg/d) and both aspirin and clopidogrel for 4 weeks. Platelet function in whole blood was s...
93 CitationsSource
#1Lars Marquardt (Heidelberg University)H-Index: 3
#2Andreas RufH-Index: 17
Last. Armin J. GrauH-Index: 47
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Background and Purpose— The aim of this study was to evaluate the time course of platelet activation after ischemic stroke and to investigate whether platelet activation and inflammation are correlated with each other. Methods— We serially determined expression of p-selectin (CD62p) and lysosome-associated membrane protein (CD63) by platelets using flow cytometry at 10 time points between days 1 and 90 in patients after ischemic stroke (n=50), in healthy subjects (n=30), and in risk factor contr...
134 CitationsSource
#1Martin Möckel (Humboldt University of Berlin)H-Index: 46
Last. A. RufH-Index: 2
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The aims of this study were to evaluate whether platelets are activated during strenuous exercise in healthy athletes. Also, to determine the impact of plasmin and thrombin activity and catecholamine release. Previous studies have shown activation of the hemostatic system after competitive exercise, but platelet activation was thought to be absent in trained athletes. The impact of thrombin and other potent platelet activators is still a matter for debate. We examined 30 healthy triathletes duri...
37 CitationsSource
#1Timm Dickfeld (TUM: Technische Universität München)H-Index: 12
#1Timm Dickfeld (TUM: Technische Universität München)H-Index: 5
Last. Meinrad Gawaz (TUM: Technische Universität München)H-Index: 27
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Abstract The blockade of platelet glycoprotein IIb–IIIa (GPIIb–IIIa) was recently introduced as a new antiplatelet strategy. At present, various GPIIb–IIIa inhibitors are available to treat patients with acute coronary syndrome or when undergoing percutaneous coronary interventions. The current study systematically evaluates the antiplatelet effects of GPIIb–IIIa inhibitors in clinical use. Using conformation-dependent monoclonal antibodies [ligand-induced binding sites (LIBS-1), PMI-1] and flow...
38 CitationsSource
#1Suzanne Fateh-Moghadam (Humboldt University of Berlin)H-Index: 15
#1S. Fateh-Moghadam (Humboldt University of Berlin)H-Index: 8
Last. Meinrad GawazH-Index: 88
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Background—Transplant vasculopathy is the main limiting factor of the long-term success of heart transplantation. We sought to establish the role of platelets in the development and progression of transplant vasculopathy. Methods and Results—Platelet analysis and intracoronary ultrasound examination were performed in 78 heart transplant recipients. Quantitative intracoronary ultrasound was used to define the severity of disease at baseline (48.8±4.5 months after transplantation) and at 1-year fo...
69 CitationsSource
#1Meinrad Gawaz (TUM: Technische Universität München)H-Index: 27
#2Andreas RufH-Index: 17
Last. Albert SchömigH-Index: 102
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Resting platelets contain a substantial internal pool of GPIIb-IIIa complexes that is exposed on the surface of activated platelets. Whether the exposure of internal GPIIb-IIIa complexes on the activated platelet surface affects therapy with GPIIb-IIIa antagonists is poorly understood. We addressed this issue in thirteen patients who underwent elective coronary stenting and received abciximab. Platelet aggregation, surface expression of GPIIb-IIIa and P-selectin, receptor blockade of GPIIb-IIIa,...
47 CitationsSource
#1L. Röcker (FU: Free University of Berlin)H-Index: 19
#2S. GünayH-Index: 1
Last. Martin MöckelH-Index: 46
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■ Isometric exercise is a popular form of physical activity for many people. Only few studies exist on the effects of this type of exercise on the hemostatic system. Eleven male healthy subjects (21- 42 years) of varying fitness levels were investigated before, immediately after and 10 min after strenuous isometric exercise of the dominant arm. Blood samples were drawn by repetitive puncture from both the exercising and the contralateral arm. The following variables were studied: Prothrombin tim...
18 CitationsSource
#1Martin Möckel (Humboldt University of Berlin)H-Index: 46
#2Natalie-Viviane Ulrich (Humboldt University of Berlin)H-Index: 1
Last. Ulrich Frei (Humboldt University of Berlin)H-Index: 61
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17 CitationsSource