Identification and Characterization of a Streptococcus pyogenes Operon Involved in Binding of Hemoproteins and Acquisition of Iron

The hemolytic Streptococcus pyogenes can use a variety of heme compounds as an iron source. In this study, we investigate hemoprotein utilization by S. pyogenes . We demonstrate that surface proteins contribute to the binding of hemoproteins to S. pyogenes . We identify an ABC transporter from the iron complex family named sia for streptococcal iron acquisition, which consists of a lipoprotein ( siaA ), membrane permease ( siaB ), and ATPase (...