Infection and Immunity
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#1Andreas J. Bäumler (UC Davis: University of California, Davis)H-Index: 101
#1Katja FreundtH-Index: 2
#2Christian HerzmannH-Index: 16
Last. Cordula Stamme (University of Lübeck)H-Index: 9
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Respiratory infections by Gram-negative bacteria are a major cause of global morbidity and mortality. Alveolar macrophages (AMs) play a central role in maintaining lung immune homeostasis and host defense by sensing pathogens via pattern recognition receptors (PRR). The PRR Toll-like receptor (TLR) 4 is a key sensor of lipopolysaccharide (LPS) from Gram-negative bacteria. Pulmonary surfactant is the natural microenvironment of AMs. Surfactant protein A (SP-A), a multifunctional host defense coll...
#1Saurabh Pandey (Jamia Hamdard)H-Index: 9
#2Sashi Kant (University of Colorado Denver)H-Index: 8
Last. Deeksha Tripathi (Central University of Rajasthan)H-Index: 8
view all 4 authors...
Macrophages are key arsenals of the immune system against invaders. After compartmental isolation of a pathogen in phagosomes, the host immune response attempts to neutralize the pathogen. However, pathogens possess the ability to subvert these assaults and can also convert macrophages into their replicative niche. The multiple host defense evasion mechanisms employed by these pathogens like phagosome maturation arrest, molecular mimicry through secretory antigens, interference with host signali...
#1Natalie Iannuzo (UA: University of Arizona)
#2Michael Insel (UA: University of Arizona)H-Index: 3
Last. Julie G. Ledford (UA: University of Arizona)H-Index: 17
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Studies have shown that club cell secretory protein (CC16) plays important protective roles in the lungs, yet its complete biological functions are unclear. We devised a translational mouse model in order to investigate the impact of early life infections, in the context of CC16 deficiency, on lung function in adult mice. CC16 sufficient (WT) and deficient (CC16-/-) mice were infected with Mycoplasma pneumoniae (Mp) as weanlings and assessed as adults ( e arly null l ife null i nfection null m o...
#2Lea Novak (UAB: University of Alabama at Birmingham)H-Index: 28
Last. W. Edward SwordsH-Index: 29
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Patients with cystic fibrosis (CF) experience lifelong respiratory infections which are a significant cause of morbidity and mortality. These infections are polymicrobial in nature, and the predominant bacterial species undergo a predictable series of changes as patients age. Young patients have populations dominated by opportunists that are typically found within the microbiome of the human nasopharynx, such as nontypeable Haemophilus influenzae (NTHi); these are eventually supplanted and the p...
#1Alexander I. Ward (Lond: University of London)H-Index: 4
#2Michael D. Lewis (Lond: University of London)H-Index: 32
Last. John M. Kelly (Lond: University of London)H-Index: 56
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Trypanosoma cruzi is the etiological agent of Chagas disease. Following T cell mediated suppression of the acute phase infection, this intracellular eukaryotic pathogen persists long-term in a limited sub-set of tissues at extremely low-levels. The reasons for this tissue-specific chronicity are not understood. Using a dual bioluminescent:fluorescent reporter strain and highly sensitive tissue imaging that allows experimental infections to be monitored at single-cell resolution, we have undertak...
#1Nicole P. Giordano (University of Oklahoma Health Sciences Center)H-Index: 6
#2Joshua A. Mettlach (University of Oklahoma Health Sciences Center)H-Index: 2
Last. Zachary D. Dalebroux (University of Oklahoma Health Sciences Center)H-Index: 13
view all 3 authors...
Enterobacteriaceae use the periplasmic domain of the conserved inner membrane protein, PbgA/YejM, to regulate lipopolysaccharide (LPS) biogenesis. Salmonella enterica serovar Typhimurium (S. Typhimurium) relies on PbgA to cause systemic disease in mice and this involves functional interactions with LapB/YciM, FtsH, and LpxC. Escherichia coli PbgA interacts with LapB, an adaptor for the FtsH protease, via the transmembrane segments. LapB and FtsH control proteolysis of LpxC, the rate-limiting LPS...
#1Gene GodboldH-Index: 3
#2Anthony D. KappellH-Index: 14
Last. Krista L. TernusH-Index: 5
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To identify sequences with a role in microbial pathogenesis, we assessed the adequacy of their annotation by existing controlled vocabularies and sequence databases. Our goal was to regularize descriptions of microbial pathogenesis for improved integration with bioinformatic applications. Here we review the challenges of annotating sequences for pathogenic activity. We relate the categorization of more than 2750 sequences of pathogenic microbes through a controlled vocabulary called Functions of...
#1Junxia Cui (Shanghai Ocean University)H-Index: 3
#2Liping Gu (SJTU: Shanghai Jiao Tong University)
Last. Tianjun XuH-Index: 6
view all 6 authors...
Upon recognition of the pathogen components by PRR (pattern recognition receptors), then the cells could be activated to produce inflammatory cytokines and type I interferons. The inflammation is tightly modulated by the host to prevent inappropriate inflammatory responses. MicroRNAs (miRNAs) are non-coding and small RNAs that can inhibit gene expression and participate in various biological functions, including maintaining a balanced immune response in the host. To maintain the balance of the i...
#1Lydia A. Sweet (Anschutz Medical Campus)H-Index: 1
#2Sharon K. Kuss-Duerkop (Anschutz Medical Campus)
Last. A. Marijke Keestra-Gounder (Anschutz Medical Campus)
view all 3 authors...
Endoplasmic reticulum (ER) stress is intimately linked with inflammation in response to pathogenic infections. ER stress occurs when cells experience a buildup of misfolded or unfolded protein during times of perturbation, such as infections, which facilitates the unfolded protein response (UPR). The UPR involves multiple host pathways in an attempt to re-establish homeostasis, which oftentimes leads to inflammation and cell death if unresolved. The UPR is activated to help resolve some bacteria...
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