Amyloid-beta-induced Degeneration of Human Brain Pericytes Is Dependent on the Apolipoprotein E Genotype

A bstract : Amyloid‐β (Aβ) deposition in cerebral vessels (cerebral amyloid angiopathy, CAA) is accompanied by degeneration of vascular cells, including pericytes and smooth muscle cells. Previous studies indicated that specific Aβ protein isoforms are toxic for cultured human brain pericytes and smooth muscle cells. In particular, Aβ 1–40 carrying the E22Q mutation, as in hereditary cerebral hemorrhage with amyloidosis of the Dutch type...