Annals of the New York Academy of Sciences
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#1Meilin Zhu (MIT: Massachusetts Institute of Technology)
#2Megan W. Tse (MIT: Massachusetts Institute of Technology)
Last. Paul C. Blainey (MIT: Massachusetts Institute of Technology)H-Index: 35
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Antibiotic resistance is a worldwide and growing clinical problem. With limited drug development in the antibacterial space, combination therapy has emerged as a promising strategy to combat multidrug-resistant bacteria. Antibacterial combinations can improve antibiotic efficacy and suppress antibacterial resistance through independent, synergistic, or even antagonistic activities. Combination therapies are famously used to treat viral and mycobacterial infections and cancer. However, antibacter...
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#1John Osei Sekyere (University of Pretoria)H-Index: 15
#2Melese Abate Reta (University of Pretoria)H-Index: 7
Last. P.B. Fourie (University of Pretoria)H-Index: 15
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In the following systematic review and meta-analyses, we report several conclusions about resistance to carbapenem and polymyxin last-resort antibiotics for treating multidrug-resistant bacterial infections among pregnant women and infants. Resistance to carbapenems and polymyxins is increasing, even in otherwise vulnerable groups such as pregnant women, toddlers, and infants, for whom therapeutic options are limited. In almost all countries, carbapenem-/polymyxin-resistant Klebsiella pneumoniae...
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#1Didier Swingedouw (University of Bordeaux)H-Index: 35
#2Adrien Bily (University of Bordeaux)
Last. Matthew Menary (École Polytechnique)
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CMIP5 models have been shown to exhibit rapid cooling events in their projections of the North Atlantic subpolar gyre. Here, we analyze the CMIP6 archive, searching for such rapid cooling events in the new generation of models. Four models out of 35 exhibit such instabilities. The climatic impacts of these events are large on decadal timescales, with a substantial effect on surface temperature over Europe, precipitation pattern in the tropics-most notably the Sahel and Amazon regions-and a possi...
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#1Francisco Stefânio Barreto (UFC: Federal University of Ceará)H-Index: 7
#2Wesley Lyeverton Correia Ribeiro (UFC: Federal University of Ceará)H-Index: 13
Last. Danielle Macedo (UFC: Federal University of Ceará)H-Index: 31
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Maternal separation (MS) is a risk factor for major depressive disorder. Both cancer and depression seem to share a common biological link. Here, we evaluated the progression of melanoma and the underlying mechanisms related to this progression, namely cell proliferation and apoptosis, in adult female mice exposed to MS. Female C57BL/6 mice were exposed to MS for 60 min/day during the first 2 postnatal weeks (here called MS mice) or left undisturbed (here called non-MS mice). Melanoma cells were...
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#1Heather Tallis (University of California, Berkeley)H-Index: 35
#2Joseph Fargione (TNC: The Nature Conservancy)H-Index: 39
Last. Christina M. Kennedy (TNC: The Nature Conservancy)H-Index: 18
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Spatial prioritization is a critical step in conservation planning, a process designed to ensure that limited resources are applied in ways that deliver the highest possible returns for biodiversity and human wellbeing. In practice, many spatial prioritizations fall short of their potential by focusing on places rather than actions, and by using data of snapshots of assets or threats rather than estimated impacts. We introduce spatial action mapping as an approach that overcomes these shortfalls...
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#1Francisco Estrada (UNAM: National Autonomous University of Mexico)H-Index: 12
#2W. J. Wouter Botzen (UU: Utrecht University)H-Index: 51
The Nationally Determined Contributions (NDCs) represent the world's first effort toward the Paris Agreement goal of keeping global temperature increase well below 2 °C and pursuing 1.5 °C. Little is known about how much the proposed mitigation efforts can reduce the risks and economic damages from unabated climate change and about the consequences if key emitters drop the Paris Agreement. Here, we use CLIMRISK, an integrated assessment model designed to support climate policy at the global, nat...
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#1Whitney Schott (UPenn: University of Pennsylvania)H-Index: 8
#2Belinda Richardson (UC Davis: University of California, Davis)
Last. Stephen A. Vosti (UC Davis: University of California, Davis)H-Index: 36
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Micronutrient powder (MNP) can reduce iron deficiency in young children, which has been well established in efficacy trials. However, the cost of different delivery platforms has not been determined. We calculated the cost and cost-efficiency of distributed MNP through community-based mechanisms and in health facilities in a primarily rural district in Uganda. An endline survey (n = 1072) identified reach and adherence. During the 9-month pilot, 37,458 (community platform) and 12,390 (facility p...
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#1Justine Noel (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 5
#2M. Cecilia Berin (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 37
Allergic diseases, including asthma, food allergy, eczema, and allergic rhinitis, are common diseases increasing in prevalence. Allergy, a failure of immune tolerance to innocuous environmental allergens, is characterized by allergen-specific immune responses, including IgE antibodies and T helper and T follicular helper cells producing type 2 cytokines. Despite the central role of adaptive immunity in pathophysiology of allergy, there is a growing body of evidence indicating an important role f...
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Acankoreagenin (ACK, also known as acankoreanogenin and HLEDA) and impressic acid are two lupane-type triterpenes that can be isolated from various Acanthopanax and Schefflera species. They efficiently block activation of the NF-κB signaling pathway and the release of proinflammatory cytokines and/or the action of inflammation mediators (HMGB1, iNOS, and NO). These effects are the basis for the antiviral and anticancer activities reported with these pentacyclic compounds or their various glycosi...
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#1Tianjiao Ma (CAS: Chinese Academy of Sciences)
#2Wen Chen (CAS: Chinese Academy of Sciences)
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