Bmp in Podocytes Is Essential for Normal Glomerular Capillary Formation
Volume: 19, Issue: 4, Pages: 685 - 694
Published: Apr 1, 2008
Abstract
Bone morphogenetic protein (BMP) 4 exerts multiple biological effects on kidney and ureter development. To examine the role of BMP4 in glomerular morphogenesis, we generated transgenic mice with altered BMP4 function in podocytes by conferring tissue-specificity with the nephrin (Nphs1) promoter. At birth, Tg(Nphs1-Nog) mice, which had loss of BMP4 function in podocytes, were found to have glomerular microaneurysms, collapsed glomerular...
Paper Details
Title
Bmp in Podocytes Is Essential for Normal Glomerular Capillary Formation
Published Date
Apr 1, 2008
Volume
19
Issue
4
Pages
685 - 694
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