Long-Term Follow-Up of a Large Active Surveillance Cohort of Patients With Prostate Cancer

Published on Jan 20, 2015in Journal of Clinical Oncology32.956
· DOI :10.1200/JCO.2014.55.1192
Laurence Klotz85
Estimated H-index: 85
(U of T: University of Toronto),
Danny Vesprini33
Estimated H-index: 33
(U of T: University of Toronto)
+ 6 AuthorsAndrew Loblaw35
Estimated H-index: 35
(U of T: University of Toronto)
Purpose Active surveillance is increasingly accepted as a treatment option for favorable-risk prostate cancer. Long-term follow-up has been lacking. In this study, we report the long-term outcome of a large active surveillance protocol in men with favorable-risk prostate cancer. Patients and Methods In a prospective single-arm cohort study carried out at a single academic health sciences center, 993 men with favorable- or intermediate-risk prostate cancer were managed with an initial expectant approach. Intervention was offered for a prostate-specific antigen (PSA) doubling time of less than 3 years, Gleason score progression, or unequivocal clinical progression. Main outcome measures were overall and disease-specific survival, rate of treatment, and PSA failure rate in the treated patients. Results Among the 819 survivors, the median follow-up time from the first biopsy is 6.4 years (range, 0.2 to 19.8 years). One hundred forty-nine (15%) of 993 patients died, and 844 patients are alive (censored rate, 8...
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