The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases
Abstract
The management of RA, SpA, psoriasis and inflammatory bowel disease has significantly improved over the last decade with the addition of tumour necrosis factor inhibitors (anti-TNFs) to the therapeutic armamentarium. Immunogenicity in response to monoclonal antibody therapies (anti-drug antibodies) may give rise to low serum drug levels, loss of therapeutic response, poor drug survival and/or adverse events such as infusion reactions. To combat...
Paper Details
Title
The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases
Published Date
Aug 14, 2013
Journal
Volume
53
Issue
2
Pages
213 - 222
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