OBJECTIVE Activated synovial fibroblasts are key effector cells in rheumatoid arthritis (RA). Selectively depleting these based upon their expression of fibroblast activation protein (FAP) is an attractive therapeutic approach. Here we introduce FAP imaging of inflamed joints using [68Ga]Ga-FAPI-04 in an RA patient, and aim to assess feasibility of anti-FAP targeted photodynamic therapy (FAP-tPDT) ex vivo using 28H1-IRDye700DX on RA synovial explants. METHODS Remnant synovial tissue from RA pati...
#1Mark C Hwang(University of Texas Health Science Center at Houston)H-Index: 2
#2MinJae Lee(UTSW: University of Texas Southwestern Medical Center)H-Index: 21
Last. John D. Reveille(University of Texas Health Science Center at Houston)H-Index: 116
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OBJECTIVES Little is known with certainty about the natural history of spinal disease progression in Ankylosing Spondylitis (AS). Our objective was to discover if there were distinct patterns of change in vertebral involvement over time and to study associated clinical factors. METHODS Data were analyzed from the Prospective Study of Outcomes in Ankylosing Spondylitis (PSOAS) observational cohort. All patients met modified New York Criteria for AS and had ≥2 sets of radiographs scored by modifie...
OBJECTIVE Association of IgA vasculitis (IgAV) and inflammatory bowel diseases (IBD) is rarely described, mainly during anti-TNF-α therapy. We aimed to describe the association of IgAV and IBD. METHODS We retrospectively analyzed the association of IgAV and IBD through the implication of the GETAID and FVSG networks. Characteristics of IBD and IgAV were collected using a standardized case report form. RESULTS Forty-three cases were included. IBD (mainly Crohn's disease (CD) in 58%) preceded IgAV...
Last. Lene Terslev(UCPH: University of Copenhagen)H-Index: 33
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OBJECTIVES The role of musculoskeletal ultrasound (MSUS) in routine care for diagnosing arthritis is not fully elucidated, but US is more sensitive than clinical joint examination for detecting synovitis. Therefore, the use of US may facilitate diagnosis of arthritis. The aim of the study was to assess if MSUS examination of hands and feet in relation to the first clinical visit had an impact on the time to reach a final diagnosis and the number of clinical follow-up visits needed after first co...
Last. John G. Hanly(Dal: Dalhousie University)H-Index: 65
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OBJECTIVE The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) was recently developed as a measure of susceptibility to adverse outcomes in systemic lupus erythematosus (SLE). We aimed to externally validate the SLICC-FI in a prevalent cohort of individuals with more longstanding SLE. METHODS This secondary analysis included data from a single-centre prospective cohort of adult patients with established SLE (disease duration >15 months at enrolment). The baseline vis...
OBJECTIVES Morning stiffness (MS) is characteristic for Rheumatoid Arthritis (RA) and associates with markers of systemic and local inflammation in RA-patients. In patients with arthralgia, MS is a cardinal symptom to recognize arthralgia at-risk for RA-development (i.e. clinically suspect arthralgia, CSA). In CSA, MS is also assumed to reflect inflammation, but this has never been studied. Therefore we aimed to study whether MS in CSA-patients is associated with systemic- and subclinical joint-...
OBJECTIVES This retrospective study compared MRI and US findings among patients with Sjogren's syndrome (SS) over a wide age range. METHODS Ninety patients with SS aged 8-84 years who had undergone both MRI and US examinations were divided into four groups according to age, as follows: null 69 years, 16 patients. Imaging findings of parotid glands (PGs) and submandibular glands (SMGs) were compared among the four groups. Furthermore, the relationships within and between imaging findings and seve...