Role of Oligosaccharide Residues of IgG1-Fc in FcγRIIb Binding

Engagement of Fcγ receptors (FcγRs) with the Fc region of IgG elicits immune responses by leukocytes. The recent crystal structure of FcγRIII in complex with IgG-Fc has provided details of molecular interactions between these components (Sondermann, P., Huber, R., Oosthuizen, V., and Jacob, U. (2000) Nature406, 267–273). One of the most intriguing issues is that glycosylation of IgG-Fc is essential for the recognition by FcγRs although the...