Yusuke Mimura
BlackRock
Binding siteCrystal structureFragment crystallizable regionInternal medicineSurgeryAntigenMolecular biologyAntibodyReceptorChemistryImmunologyGlycanLung cancerSurvival rateExacerbationGlycosylationOligosaccharideIdiopathic pulmonary fibrosisHemoperfusionFc fragmentAnesthesiaCancer researchPlasma protein bindingBiochemistryMedicineCrystallographyBiologyGastroenterology
35Publications
14H-index
2,469Citations
Publications 34
Newest
#2Yuka Mimura-KimuraH-Index: 6
Last. Yusuke MimuraH-Index: 14
view all 9 authors...
Background: Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) are episodes of acute respiratory worsening characterized by diffuse alveolar damage superimposed on usual interstitial pneumonia. Direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) is reported to have beneficial effects on the respiratory status and outcome in patients with AE-IPF although its mechanism of action is not fully elucidated. Objective: To investigate whether and how the PMX-immobilized...
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#1Tsunahiko Hirano (Yamaguchi University)H-Index: 21
#2K. Doi (Yamaguchi University)H-Index: 1
Last. Tomoyuki Kakugawa (Yamaguchi University)H-Index: 2
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Sedentary behavior and cognitive impairment have a direct impact on patients' outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linkage between a proapoptotic protein, growth differentiation factor (GDF)-15, and MCR. Physical activity (PA), cognitive function (Japanese version of the Montreal Cognitive Assessment: MOCA-J), and the ...
3 CitationsSource
#1Yoriyuki MurataH-Index: 4
#2Keisuke AoeH-Index: 30
Last. Yusuke MimuraH-Index: 14
view all 3 authors...
Purpose of reviewThe causes of exudative pleural effusions are diverse and frequently remain unclear despite exhaustive examinations. Recently recognized IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder that can affect nearly any organ including the lungs. This review will focus on the
7 CitationsSource
#1Takashi KarashimaH-Index: 1
#2Yuka Mimura-KimuraH-Index: 6
Last. Yusuke MimuraH-Index: 14
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BACKGROUND: Intrapulmonary percussive ventilation (IPV) is used for airway clearance and delivery of aerosol medications, including bronchodilators. Despite the common use of IPV for drug delivery, few data are available regarding optimization of inhalation therapy with IPV. In this study, we investigated the influence of IPV setting parameters and lung mechanics on drug delivery via IPV alone. METHODS: An IPV device was connected to a lung model via a trachea model and a flow analyzer. Albutero...
3 CitationsSource
#1Yusuke MimuraH-Index: 14
#2Toshihiko Katoh (LMB: Laboratory of Molecular Biology)H-Index: 10
Last. Pauline M. RuddH-Index: 28
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Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex-type oligosaccharide attached to Asn297 of the Fc is essential for antibody effector functions, fucose and outer-arm sugars attached to the core heptasaccharide that generate structural heterogeneity (glycoforms) exhibit unique biological activities. Hence, efficient and quantitative glycan analysis techniques have been increasingly important fo...
75 CitationsSource
#1Yoriyuki MurataH-Index: 4
#2Keisuke AoeH-Index: 30
Last. Yusuke MimuraH-Index: 14
view all 10 authors...
: The cause of pleural effusion remains uncertain in approximately 15% of patients despite exhaustive evaluation. As recently described immunoglobulin (Ig)G4-related disease is a fibroinflammatory disorder that can affect various organs, including the lungs, we investigate whether idiopathic pleural effusion includes IgG4-associated etiology. Between 2000 and 2012, we collected 830 pleural fluid samples and reviewed 35 patients with pleural effusions undiagnosed after pleural biopsy at Yamaguchi...
4 CitationsSource
#1Hiroyuki TaoH-Index: 11
#2Yuka Mimura-KimuraH-Index: 6
Last. Kazunori OkabeH-Index: 11
view all 8 authors...
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#1Keiji OishiH-Index: 6
#2Keisuke AoeH-Index: 30
Last. Masafumi Yano (Yamaguchi University)H-Index: 41
view all 9 authors...
: Objective Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) are fatal episodes of acute respiratory worsening of unknown etiology. Previous studies on acute respiratory distress syndrome have shown that direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) can have a beneficial effect on the respiratory status. This retrospective study investigated the prognosis and survival outcome of patients with AE-IPF who underwent PMX-DHP. Methods We examined the records ...
19 CitationsSource
#1Keiji OishiH-Index: 6
#2Keisuke AoeH-Index: 30
Last. Masafumi Yano (Yamaguchi University)H-Index: 41
view all 10 authors...
Background: Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) are fatal episodes of acute respiratory worsening of unknown etiology. Previous studies on acute respiratory distress syndrome have shown that direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP) beneficially impact respiratory status. Aimes: To investigate the prognosis and survival outcome of patients with AE-IPF who underwent PMX-DHP. Methods: We examined records of 50 patients with AE-IPF treated in...
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#1Masashi FurukawaH-Index: 12
Last. Kazunori OkabeH-Index: 11
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Background: Lung cancer is one of the refractory malignancies and the leading cause of cancer-related death worldwide. Although prognosis of lung cancer was improved by the anticancer drugs and molecular targeted therapies, the results are not sufficient. Cellular senescence is irreversible cell cycle arrest. The drug-dependent induction of cellular senescence in neoplastic cells is considered an important tumor suppressive mechanism. 5-aza-2’-deoxycytidine (5-aza-dC) causes cellular senescence ...
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