Prostaglandin E₂deficiency uncovers a dominant role for thromboxane A₂in house dust mite-induced allergic pulmonary inflammation

Prostaglandin E 2 (PGE 2 ) is an abundant lipid inflammatory mediator with potent but incompletely understood anti-inflammatory actions in the lung. Deficient PGE 2 generation in the lung predisposes to airway hyperresponsiveness and aspirin intolerance in asthmatic individuals. PGE 2 -deficient ptges −/− mice develop exaggerated pulmonary eosinophilia and pulmonary arteriolar smooth-muscle hyperplasia compared with PGE 2 -sufficient controls...