Cardiac Specific Leucine-Rich Repeat Containing 10 (LRRC10) Protein Interacts with and Regulates the Cav1.2 L-Type Ca2+ Channels

Cardiac L-type Ca2+ channels (LTCC) play essential role in multiple cellular processes including excitation-contraction coupling, signaling and gene regulation. Diverse families of regulatory and scaffolding proteins regulate the LTCCs in the cardiomyocytes. Leucine-rich repeat containing 10 (LRRC10) is a cardiac-specific scaffolding protein that plays a critical role in heart development and function. Recently we have demonstrated that the...