Biophysical Journal
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#1Christopher C. Price (UPenn: University of Pennsylvania)H-Index: 5
#2Jairaj Mathur (WashU: Washington University in St. Louis)
Last. Vivek B. Shenoy (UPenn: University of Pennsylvania)H-Index: 78
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Abstract null Mechanotransduction describes activation of gene expression by changes in the cell's physical microenvironment. Recent experiments show that mechanotransduction can lead to long-term "mechanical memory," in which cells cultured on stiff substrates for sufficient time (priming phase) maintain altered phenotype after switching to soft substrates (dissipation phase) as compared to unprimed controls. The timescale of memory acquisition and retention is orders of magnitude larger than t...
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#1Sara M. Connelly (UR: University of Rochester)H-Index: 9
#2Rajashri Sridharan (UR: University of Rochester)
Last. Mark E. Dumont (UR: University of Rochester)H-Index: 29
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Abstract null G protein coupled receptors (GPCRs) comprise a large superfamily of transmembrane receptors responsible for transducing responses to the binding of a wide variety of hormones, neurotransmitters, ions, and other small molecules. There is extensive evidence that GPCRs exist as homo-and hetero-oligomeric complexes, however, in many cases, the role of oligomerization and the extent to which it occurs at low, physiological, levels of receptor expression in cells remain unclear. We repor...
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#1Federico Sebastiani (UniFI: University of Florence)H-Index: 22
#2Hanna Michlits (BOKU: University of Natural Resources and Life Sciences, Vienna)H-Index: 5
Last. Giulietta Smulevich (UniFI: University of Florence)H-Index: 53
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Abstract null null Monoderm bacteria utilize coproheme decarboxylases (ChdCs) to generate heme b by a stepwise decarboxylation of two propionate groups of iron coproporphyrin III (coproheme), forming two vinyl groups. This work focuses on actinobacterial ChdC from Corynebacterium diphtheriae (CdChdC) to elucidate the hydrogen peroxide-mediated decarboxylation of coproheme via monovinyl monopropionyl deuteroheme (MMD) to heme b, with the principal aim being to understand the reorientation mechani...
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#1Itay Gelber (BGU: Ben-Gurion University of the Negev)
#2Alexander Aranovich (BGU: Ben-Gurion University of the Negev)H-Index: 4
Last. Itzhak Fishov (BGU: Ben-Gurion University of the Negev)H-Index: 20
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Abstract null Segregation of the replicating chromosome from a single to two nucleoid bodies is one of the major processes in growing bacterial cells. The segregation dynamics is tuned by intricate interactions with other cellular processes such as growth and division, ensuring flexibility in a changing environment. We hypothesize that the internal stochasticity of the segregation process may be the source of cell-to-cell phenotypic variability, in addition to the well-established gene expressio...
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#1Sreenath Balakrishnan (IITs: Indian Institutes of Technology)H-Index: 4
#2Shilpa R. Raju (IISc: Indian Institute of Science)H-Index: 3
Last. G. K. Ananthasuresh (IISc: Indian Institute of Science)H-Index: 35
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Abstract null null Nuclear morphology is an important indicator of cell function. It is regulated by a variety of factors such as the osmotic pressure difference between the nucleoplasm and cytoplasm, cytoskeletal forces, elasticity of the nuclear envelope and chromosomes. Nucleus shape and size are typically quantified using multiple geometrical quantities that are not necessarily independent of one another. This interdependence makes it difficult to decipher the implications of changes in nucl...
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#1Sarah A. Otieno (Binghamton University)H-Index: 1
#2Wei Qiang (Binghamton University)H-Index: 20
Abstract null The pH-low insertion peptide (pHLIP) and its analogs sense the microenvironmental pH variations in tumorous cells and serve as useful anticancer drug deliveries. The pHLIP binds peripherally to membranes and adopts random coil conformation at the physiological pH. The peptide switches from random coil to α-helical conformation and inserts unidirectionally into membrane bilayers when pH drops below a critical transition value that has been routinely determined by the Trp fluorescenc...
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#1Zixiang Leonardo Liu (Brown University)
#2He Li (Brown University)H-Index: 14
Last. George Em Karniadakis (Brown University)H-Index: 110
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Abstract null Because of their compromised deformability, heat denatured erythrocytes have been used as labeled probes to visualize spleen tissue or to assess the ability of the spleen to retain stiff red blood cells (RBCs) for over three decades, e.g., see Looareesuwan et al. N. Engl. J. Med. (1987). Despite their good accessibility, it is still an open question how heated RBCs compare to certain diseased RBCs in terms of their biomechanical and biorheological responses, which may undermine the...
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#1Yimei Lu (NUS: National University of Singapore)H-Index: 16
#2Daiwen Yang (NUS: National University of Singapore)H-Index: 34
Abstract null Fatty acid binding proteins (FABPs) can facilitate the transfer of long-chain fatty acids between intracellular membranes across considerable distances. The transfer process involves fatty acids, their donor membrane and acceptor membrane, and FABPs, implying that potential protein-membrane interactions exist. Despite intensive studies on FABP-membrane interactions, the interaction mode remains elusive, and the protein-membrane association and dissociation rates are inconsistent. I...
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#1Giacomo Bartolucci (MPG: Max Planck Society)
#2Omar Adame-Arana (Weizmann Institute of Science)H-Index: 2
Last. Christoph Weber (MPG: Max Planck Society)H-Index: 40
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Abstract null Phase separation and transitions among different molecular states are ubiquitous in living cells. Such transitions can be governed by local equilibrium thermodynamics or by active processes controlled by biological fuel. It remains largely unexplored how the behavior of phase-separating systems with molecular transitions differs between thermodynamic equilibrium and cases in which the detailed balance of the molecular transition rates is broken because of the presence of fuel. Here...
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#1Andrés Bustamante (University of Chile)H-Index: 8
#2Rodrigo Rivera (University of Chile)
Last. Mauricio Baez (University of Chile)H-Index: 11
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Abstract null null Domain swapping is a mechanism of protein oligomerization by which two or more subunits exchange structural elements to generate an intertwined complex. Numerous studies support a diversity of swapping mechanisms in which structural elements can be exchanged at different stages of the folding pathway of a subunit. Here, we used single-molecule optical tweezers technique to analyze the swapping mechanism of the forkhead DNA-binding domain of human transcription factor FoxP1. Fo...
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