Ravi C. Balijepalli
University of Wisconsin-Madison
Protein subunitL-type calcium channelBiophysicsInternal medicineEndocrinologyMutantPatch clampMolecular biologyCardiologyHEK 293 cellsElectrophysiologyChemistryVoltage-dependent calcium channelMyocyteDilated cardiomyopathyCaveolin 3Cav1.2Heart failurehERGLong QT syndromeCaveolaeIon channelScaffold proteinMedicineBiologyCell biology
78Publications
22H-index
1,978Citations
Publications 78
Newest
#1Leonid Tyan (UW: University of Wisconsin-Madison)H-Index: 11
#2Jason D. Foell (UW: University of Wisconsin-Madison)H-Index: 12
Last. Timothy J. Kamp (UW: University of Wisconsin-Madison)H-Index: 56
view all 12 authors...
KEY POINTS: Mutations in the caveolae scaffolding protein, caveolin-3 (Cav3), have been linked to the long QT type 9 inherited arrhythmia syndrome (LQT9) and the cause of underlying action potential duration prolongation is incompletely understood. In the present study, we show that LQT9 Cav3 mutations, F97C and S141R, cause mutation-specific gain of function effects on Cav 1.2-encoded L-type Ca2+ channels responsible for ICa,L and also cause loss of function effects on heterologously expressed ...
10 CitationsSource
#1Peter Wright (NIH: National Institutes of Health)H-Index: 73
#2Navneet Bhogal (NIH: National Institutes of Health)H-Index: 5
Last. Julia Gorelik (NIH: National Institutes of Health)H-Index: 48
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Summary Cardiomyocytes from the apex but not the base of the heart increase their contractility in response to β 2 -adrenoceptor (β 2 AR) stimulation, which may underlie the development of Takotsubo cardiomyopathy. However, both cell types produce comparable cytosolic amounts of the second messenger cAMP. We investigated this discrepancy using nanoscale imaging techniques and found that, structurally, basal cardiomyocytes have more organized membranes (higher T-tubular and caveolar densities). L...
29 CitationsSource
#1Marites T. Woon (UW: University of Wisconsin-Madison)H-Index: 4
#2Pamela A. Long (Mayo Clinic)H-Index: 7
Last. Timothy J. Kamp (UW: University of Wisconsin-Madison)H-Index: 56
view all 11 authors...
BackgroundGenetic causes of dilated cardiomyopathy (DCM) are incompletely understood. LRRC10 (leucine‐rich repeat–containing 10) is a cardiac‐specific protein of unknown function. Heterozygous muta...
7 CitationsSource
#1Marites T. WoonH-Index: 4
#2Pamela A. LongH-Index: 7
Last. Timothy J. KampH-Index: 56
view all 11 authors...
Leucine-rich repeat containing (LRR) proteins facilitate protein-protein interactions critical in a number of cellular functions including ion channel regulation. Leucine-rich repeat containing pro...
#1Ravi VaidyanathanH-Index: 15
#2Hanora Van ErtH-Index: 2
Last. Lee L. EckhardtH-Index: 17
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Introduction: In human ventricle Kir2.1 comprises the major component of IK1, but the Kir2.2 isoform dominates in the atria. Thus Kir2.2 regulation may have specific impact in atrial arrhythmias such as atrial fibrillation. Caveolin-3 (Cav3) forms caveolar rafts and plays a key role in assembling macromolecular signaling complexes for cardiac ion channels. Cav3 is implicated in ion channel misplacement in heart failure leading to atrial fibrillation. In our previous report, Kir2.1 and Cav3 assoc...
#1Di LangH-Index: 12
Last. Alexey V. GlukhovH-Index: 22
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Introduction: Caveolae represent a population of caveolin-3 (Cav3)-containing membrane microdomains housing a number of ion channels and transporters that are involved in sinoatrial node (SAN) pacemaking. Cav3 organizes these channels within macromolecular signaling complexes providing highly localized autonomic regulation of the SAN. Hypothesis: Cav3 is required for functional integrity of the SAN, synchronizing Ca release and Ca-voltage coupling. Methods: ECG telemetry, simultaneous optical ma...
#1Marites T. WoonH-Index: 4
Last. Timothy J. KampH-Index: 56
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Leucine-rich repeat containing protein 10 (LRRC10) is a cardiac-specific protein and loss of LRRC10 in LRRC10-/- mice results in dilated cardiomyopathy (DCM). Here we describe a novel mutation in h...
#1Yogananda S. Markandeya (UW: University of Wisconsin-Madison)H-Index: 8
#2Tadashi TsubouchiH-Index: 1
Last. Ravi C. Balijepalli (UW: University of Wisconsin-Madison)H-Index: 22
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Background Lamin A and C are nuclear filament proteins encoded by the LMNA gene. Mutations in the LMNA gene cause many congenital diseases known as laminopathies, including Emery–Dreifuss muscular dystrophy, Hutchinson–Gilford progeria syndrome, and familial dilated cardiomyopathy (DCM) with conduction disease. A missense mutation (N195K) in the A-type lamins results in familial DCM and sudden arrhythmic death. Objective The purpose of this study was to investigate the ion current mechanism of a...
10 CitationsSource
#1Ravi C. BalijepalliH-Index: 22
#2Leonid TyanH-Index: 11
Last. Timothy J. KampH-Index: 56
view all 5 authors...
Caveolae are discrete microdomains in cardiomyocytes that localize many ion channels and signaling proteins. Mutations in the CAV3 gene, encoding caveolin-3 (Cav-3), a muscle specific scaffolding p...
#1Jan M. Schilling (UCSD: University of California, San Diego)H-Index: 16
#2Yousuke T. Horikawa (UCSD: University of California, San Diego)H-Index: 12
Last. David M. Roth (UCSD: University of California, San Diego)H-Index: 71
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Caveolin-3 (Cav-3) plays a critical role in organizing signaling molecules and ion channels involved in cardiac conduction and metabolism. Mutations in Cav-3 are implicated in cardiac conduction abnormalities and myopathies. Additionally, cardiac-specific overexpression of Cav-3 (Cav-3 OE) is protective against ischemic and hypertensive injury, suggesting a potential role for Cav-3 in basal cardiac electrophysiology and metabolism involved in stress adaptation. We hypothesized that overexpressio...
12 CitationsSource