Cigarette smoke condensate inhibits collagen gel contraction and prostaglandin E₂ production in human gingival fibroblasts

Background Granulation tissue remodeling and myofibroblastic differentiation are critically important events during wound healing. Tobacco smoking has a detrimental effect in gingival tissue repair. However, studies evaluating the effects of cigarette smoke on these events are lacking. Material and Methods We used gingival fibroblasts cultured within free‐floating and restrained collagen gels to simulate the initial and final steps of the...