Mónica Cáceres
University of Chile
PhosphorylationInternal medicineEndocrinologyCell migrationCytoskeletonPathologyCellFocal adhesionMolecular biologyTransient receptor potential channelMatrix (biology)KinaseChemistryExtracellular matrixMyofibroblastGrowth factorGranulation tissueUrokinaseRHOAWound healingFibroblastPeriodontal diseaseActin cytoskeletonPeriodontal tissueReactive oxygen speciesCancer researchConnective tissueViability assayBiochemistryMedicineCell adhesionBiologyCell biology
Publications 34
Breast cancer is one of the most frequent cancer types worldwide and the first cause of cancer-related deaths in women. Although significant therapeutic advances have been achieved with drugs such as tamoxifen and trastuzumab, breast cancer still caused 627,000 deaths in 2018. Since cancer is a multifactorial disease, it has become necessary to develop new molecular therapies that can target several relevant cellular processes at once. Ion channels are versatile regulators of several physiologic...
#1Christian Fernández (University of Chile)H-Index: 1
#1Christian Fernández (University of Chile)H-Index: 1
Last. Mónica Cáceres (University of Chile)H-Index: 16
view all 17 authors...
Aging is a gradual biological process characterized by a decrease in cellular and organism functions. Aging-related processes involve changes in the expression and activity of several proteins. Here, we identified the transmembrane protease serine 11a (TMPRSS11a) as a new age-specific protein that plays an important role in skin wound healing. TMPRSS11a levels increased with age in rodent and human skin and gingival samples. Strikingly, overexpression of TMPRSS11a decreased cell migration and sp...
#1P. Torres (University of Chile)H-Index: 5
#2Nadia Hernández (University of Chile)H-Index: 1
Last. Vicente A. Torres (University of Chile)H-Index: 24
view all 14 authors...
Histatin-1 is a salivary antimicrobial peptide involved in the maintenance of enamel and oral mucosal homeostasis. Moreover, Histatin-1 has been shown to promote re-epithelialization in soft tissues, by stimulating cell adhesion and migration in oral and dermal keratinocytes, gingival and skin fibroblasts, endothelial cells and corneal epithelial cells. The broad-spectrum activity of Histatin-1 suggests that it behaves as a universal wound healing promoter, although this is far from being clear ...
#1Mauricio Garrido (University of Chile)H-Index: 7
#2Diego Morales (University of Chile)H-Index: 4
Last. Mónica Cáceres (University of Chile)H-Index: 16
view all 7 authors...
BACKGROUND This study aimed to evaluate the biological response of human apical papilla cells to different calcium hydroxide formulations and three tricalcium silicate-based materials. METHODS Primary cells were obtained from explants of young immature premolars. 20,000 cells adhered for 24 h over discs of Biodentine™, ProRoot®MTA, BioRoot®RCS and calcium hydroxide mixed either with sodium chloride 0.9%w/v or polyethylene glycol and UltraCal® were used to evaluate cell adhesion by scanning elect...
#1José Rivas (University of Chile)H-Index: 4
#2Nicolás Díaz (University of Chile)H-Index: 2
Last. Oscar Cerda (University of Chile)H-Index: 14
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Transient receptor potential melastatin 4 (TRPM4) is a Ca(2+) -activated nonselective cationic channel that regulates cell migration and contractility. Increased TRPM4 expression has been related to pathologies, in which cytoskeletal rearrangement and cell migration are altered, such as metastatic cancer. Here, we identify the K(+) channel tetramerization domain 5 (KCTD5) protein, a putative adaptor of cullin3 E3 ubiquitin ligase, as a novel TRPM4-interacting protein. We demonstrate that KCTD5 i...
8 CitationsSource
#1Felipe Maldonado (University of Chile)H-Index: 2
#2Diego Morales (University of Chile)H-Index: 4
Last. Mónica Cáceres (University of Chile)H-Index: 16
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BACKGROUND: The glycocalyx layer is a key structure in the endothelium. Tourniquet-induced ischemic periods are used during orthopedic surgery, and the reactive oxygen species generated after ischemia-reperfusion may mediate the shedding of the glycocalyx. Here, we describe the effects of tourniquet-induced ischemia-reperfusion and compare the effects of sevoflurane and propofol on the release of endothelial biomarkers after ischemia-reperfusion in knee-ligament surgery. METHODS: This pilot, sin...
3 CitationsSource
#1Constanza Blanco (University of Chile)H-Index: 4
#2Danna Morales (University of Chile)H-Index: 5
Last. Oscar Cerda (University of Chile)H-Index: 14
view all 15 authors...
Transient receptor potential melastatin 4 (TRPM4) is a Ca2+-activated nonselective cationic channel involved in a wide variety of physiologic and pathophysiological processes. Bioinformatics analys...
8 CitationsSource
#1María Paz Saldías (University of Chile)H-Index: 2
#2Christian Fernández (University of Chile)H-Index: 1
Last. Mónica Cáceres (University of Chile)H-Index: 16
view all 14 authors...
Aging is a gradual biological process characterized by a decrease in cell and organism functions. Gingival wound healing is one of the impaired processes found in old rats. Here, we studied the in vivo wound healing process using a gingival repair rat model and an in vitro model using human gingival fibroblast for cellular responses associated to wound healing. To do that, we evaluated cell proliferation of both epithelial and connective tissue cells in gingival wounds and found decreased of Ki6...
8 CitationsSource
#1Ignacio N. Retamal (UC: Pontifical Catholic University of Chile)H-Index: 6
#2Ramón Faustino Díaz Hernández (UC: Pontifical Catholic University of Chile)H-Index: 3
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
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Background and Objectives Methylglyoxal is a toxic product derived from glucose metabolism that plays a role in inflammation, diabetes and aging. In addition, the periodontal pathogen Tannerella forsythensis may also generate this compound. However, the effects of methylglyoxal on gingival cells are still poorly understood. In the present study, we have explored whether methylglyoxal or methylglyoxal-treated collagen may modulate cell viability, death and proliferation in gingival connective tis...
5 CitationsSource
#1Oscar Cerda (University of Chile)H-Index: 14
#2Mónica Cáceres (University of Chile)H-Index: 16
Last. Andrés Stutzin (University of Chile)H-Index: 17
view all 8 authors...
Transient receptor potential melastatin-like 4 (TRPM4) is a Ca2+-activated non-selective cation channel expressed in a wide range of human tissues. TRPM4 participates in a variety of physiological processes such as T cell activation, myogenic vasoconstriction, and allergic reactions. TRPM4 Ca2+ sensitivity is enhanced by calmodulin (CaM) and phosphathydilinositol 4, 5-bisphosphate (PI(4,5)P2) binding, as well as, under certain conditions, PKC activation. However, information as to the mechanisms...
7 CitationsSource