Patricio C. Smith
Pontifical Catholic University of Chile
EndocrinologyCell migrationPathologyCellular differentiationStromal cellChemistryExtracellular matrixMyofibroblastGrowth factorInflammationPlatelet-rich plasmaWound healingFibroblastCancer researchConnective tissueSignal transductionMedicineCell cultureBiologyCell biology
63Publications
22H-index
1,880Citations
Publications 63
Newest
#1Jorge Martínez (University of Chile)H-Index: 28
#2Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
Desmoplastic tumors correspond to a unique tissue structure characterized by the abnormal deposition of extracellular matrix. Breast tumors are a typical example of this type of lesion, a property that allows its palpation and early detection. Fibrillar type I collagen is a major component of tumor desmoplasia and its accumulation is causally linked to tumor cell survival and metastasis. For many years, the desmoplastic phenomenon was considered to be a reaction and response of the host tissue a...
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#1Diana Alvarez (UC: Pontifical Catholic University of Chile)H-Index: 15
#2Luisa F. Duarte (UC: Pontifical Catholic University of Chile)H-Index: 3
Last. Pablo A. González (UC: Pontifical Catholic University of Chile)H-Index: 30
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#1Estefanía Castillo (UC: Pontifical Catholic University of Chile)H-Index: 2
#2Luisa F. Duarte (UC: Pontifical Catholic University of Chile)H-Index: 3
Last. Pablo A. González (UC: Pontifical Catholic University of Chile)H-Index: 30
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Herpes simplex viruses (HSVs) type 1 (HSV-1) and type 2 (HSV-2) are highly prevalent in the human population, and the infections they produce are lifelong with frequent reactivations throughout life. Both viruses produce uncomfortable and sometimes painful lesions in the orofacial and genital areas, as well as herpetic gingivostomatitis, among other clinical manifestations. At present, the most common treatments against HSVs consist of nucleoside analogs that target the viral polymerases. Howeve...
1 CitationsSource
#1Diana Alvarez (UC: Pontifical Catholic University of Chile)H-Index: 15
#1Diana M. Álvarez (UC: Pontifical Catholic University of Chile)
Last. Pablo A. González (UC: Pontifical Catholic University of Chile)H-Index: 30
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Abstract Infections with herpes simplex viruses are lifelong and highly prevalent worldwide. Individuals with clinical symptoms elicited by HSVs may suffer from occasional or recurrent herpetic lesions in the orofacial and genital areas. Despite the existence of nucleoside analogues that interfere with HSV replication, such as acyclovir, these drugs are somewhat ineffective in treating skin lesions as topical formulations only reduce in one or few days the duration of the herpetic ulcers. Cetylp...
2 CitationsSource
#1Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
#2Claudia Metz (San Sebastián University)H-Index: 11
Last. Andrea Soza (UC: Pontifical Catholic University of Chile)H-Index: 18
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BACKGROUND AND OBJECTIVE During cyclosporine-induced gingival overgrowth, the homeostatic balance of gingival connective tissue is disrupted leading to fibrosis. Galectins are glycan-binding proteins that can modulate a variety of cellular processes including fibrosis in several organs. Here, we study the role of galectin-8 (Gal-8) in the response of gingival connective tissue cells to cyclosporine. METHODS We used human gingival fibroblasts and mouse NIH3T3 cells treated with recombinant Gal-8 ...
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#1Ignacio N Retamal (University of Los Andes)H-Index: 1
#1Ignacio N. Retamal (University of Los Andes)H-Index: 6
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
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OBJECTIVES: Myofibroblasts constitute a specific cell phenotype involved in connective tissue healing. Diabetes alters the wound healing response. However, it is not clear whether diabetes modifies the involvement of myofibroblasts in periodontal wounds. MATERIAL AND METHODS: Type I diabetes was induced in rats through streptozotocin injection and periodontal wounds were performed. Wound healing was evaluated histologically at 2, 5, 7 and 15 days by measuring epithelial migration, neutrophil inf...
2 CitationsSource
#1Constanza Martínez (UC: Pontifical Catholic University of Chile)H-Index: 12
#2Roberto S. Gómez (UC: Pontifical Catholic University of Chile)H-Index: 9
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
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Objectives Cell-based therapies involve the need to expand cell cultures ex vivo for their subsequent implantation in an autologous manner. An important limitation regarding this technology is the use of fetal bovine serum (FBS) that has critical safety limitations. Platelet-derived fractions represent an autologous source of growth factors that may be used for the expansion of these cell cultures. Periodontal ligament (PDL) cells comprise a heterogeneous cell population that may not necessarily...
4 CitationsSource
#1Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
#2Constanza Martínez (UC: Pontifical Catholic University of Chile)H-Index: 12
Last. Christopher A. McCulloch (U of T: University of Toronto)H-Index: 89
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After injury to periodontal tissues a healing response is initiated that includes a series of sequential phases, which enable wound closure and partial restoration of tissue structure and function. Wound closure in periodontal tissues involves the tightly regulated coordination of resident cells in epithelial and connective tissue compartments. Multiple cell populations in these compartments synergize their metabolic activities to re-establish a mucosal seal that involves the underlying periodon...
27 CitationsSource
#1L. Pavez (LMB: Laboratory of Molecular Biology)H-Index: 1
#2Nicolás Tobar (University of Chile)H-Index: 11
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
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Background and Objectives An important goal of periodontal therapy is the modulation of the inflammatory response. To this end, several pharmacological agents have been evaluated. Triclosan corresponds to an antibacterial and anti-inflammatory agent currently used in periodontal therapy. Chitosan is a natural polymer that may act as a drug delivery agent and exerts antibacterial and anti-inflammatory activities. Therefore, an association between both molecules might be useful to prevent inflamma...
4 CitationsSource
#1Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
: Myofibroblasts represent specific subpopulations of cells with important roles in tissue remodeling in both health and disease. They are not usually found in resting healthy tissues. However, they increase in number during the proliferative phase of wound healing. In these conditions, myofibroblasts secrete and organize different molecular components of the extracellular matrix that with time will reconstitute and hopefully regenerate the damaged tissue. Importantly, these cell populations mus...
2 CitationsSource