Interferon γ-dependent Induction of Human Intercellular Adhesion Molecule-1 Gene Expression Involves Activation of a Distinct STAT Protein Complex

In response to interferon γ (IFNγ), intercellular adhesion molecule-1 (ICAM-1) is expressed on human keratinocytes, a cell type that is critically involved in cutaneous inflammation. An ICAM-1 5ʹ regulatory region palindromic response element, pIγRE, has been shown to confer IFNγ-dependent transcription enhancement. By electrophoretic mobility shift assays (EMSA), pIγRE forms a distinct complex with proteins from IFNγ-treated human...