An Immunosurveillance Mechanism Controls Cancer Cell Ploidy
Abstract
Cancer cells accommodate multiple genetic and epigenetic alterations that initially activate intrinsic (cell-autonomous) and extrinsic (immune-mediated) oncosuppressive mechanisms. Only once these barriers to oncogenesis have been overcome can malignant growth proceed unrestrained. Tetraploidization can contribute to oncogenesis because hyperploid cells are genomically unstable. We report that hyperploid cancer cells become immunogenic because...
Paper Details
Title
An Immunosurveillance Mechanism Controls Cancer Cell Ploidy
Published Date
Sep 28, 2012
Journal
Volume
337
Issue
6102
Pages
1678 - 1684
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