Guido Kroemer
University of Paris
CancerCellMolecular biologyChemistryApoptosisImmunologyAutophagyImmunosurveillanceImmunogenic cell deathMitochondrionProgrammed cell deathCancer researchBiochemistryMedicineBiologyImmune systemCell biologyCancer cellCaspase
Publications 1,413
#1Philippe Pihán (University of Chile)H-Index: 7
#2Fernanda Lisbona (University of Chile)H-Index: 9
Last. Helena Vihinen (UH: University of Helsinki)H-Index: 27
view all 28 authors...
Programmed cell death is regulated by the balance between activating and inhibitory signals. Here, we have identified RECS1 (responsive to centrifugal force and shear stress 1) [also known as TMBIM...
#1Jiayin Deng (Institut Gustave Roussy)
#2Lucía Gutiérrez (CSIC: Spanish National Research Council)H-Index: 30
Last. Juncheng Pan (Institut Gustave Roussy)
view all 17 authors...
Pro-apoptotic multi-domain proteins of the BCL2 family such as BAX and BAK are well known for their important role in the induction of mitochondrial outer membrane permeabilization (MOMP), which is the rate-limiting step of the intrinsic pathway of apoptosis. Human or mouse cells lacking both BAX and BAK (due to a double knockout, DKO) are notoriously resistant to MOMP and cell death induction. Here we report the surprising finding that BAX/BAK DKO cells proliferate less than control cells expre...
#1Simone LaniniH-Index: 1
#2Stefania CaponeH-Index: 30
Last. Flavia MazzaferriH-Index: 1
view all 68 authors...
Safe and effective vaccines against coronavirus disease 2019 (COVID-19) are essential for ending the ongoing pandemic. Although impressive progress has been made with several COVID-19 vaccines alre...
#1Adriana Petrazzuolo (University of Paris)H-Index: 3
#2Maria Perez-Lanzon (University of Paris)H-Index: 5
Last. Guido Kroemer (University of Paris)H-Index: 261
view all 5 authors...
Immunogenic cell death (ICD) has initially been discovered in the context of chemotherapy. High-dose crizotinib also stimulates ICD, as we described for non-small cell lung cancer lacking activating chromosomal aberrations of ALK or ROS1, the usual targets of crizotinib, indicating that crizotinib may act through off-target effects. However, we found that low-dose of ALK inhibitors, crizotinib and ceritinib, may stimulate ICD in anaplastic large cell lymphoma, in which ALK is activated due to a ...
#4Allan Sauvat (Université Paris-Saclay)
#5Marion Leduc (Université Paris-Saclay)
Last. Hui Chen (University of Paris-Sud)
view all 15 authors...
Colorectal cancers (CRC) can be classified into four consensus molecular subtypes (CMS), among which CMS1 has the best prognosis, contrasting with CMS4 that has the worst outcome. CMS4 CRC is notoriously resistant against therapeutic interventions, as demonstrated by preclinical studies and retrospective clinical observations. Here, we report the finding that two clinically employed agents, everolimus (EVE) and plicamycin (PLI), efficiently target the prototypic CMS4 cell line MDST8. As compared...
#1Maria Paula Roberti (DKFZ: German Cancer Research Center)
#2Conrad Rauber (Heidelberg University)H-Index: 7
Last. Laurence ZitvogelH-Index: 139
view all 4 authors...
Besides tumor cell-intrinsic oncogenic pathways, host and environmental factors have a major impact on cancer immunosurveillance and the efficacy of immunotherapeutics. Several modalities of anticancer treatments including immunogenic chemotherapies and immune checkpoint inhibitors lose their efficacy in patients treated with broad-spectrum antibiotics, pointing to a key role for the gut microbiota. The complex interactions between intestinal microbes, gut immunity and anti-tumor responses const...
#1Daolin Tang (Guangzhou Medical University)H-Index: 27
#2Guido Kroemer (Institut Gustave Roussy)H-Index: 261
Last. Rui Kang (UTSW: University of Texas Southwestern Medical Center)H-Index: 30
view all 3 authors...
Across a broad range of human cancers, gain-of-function mutations in RAS genes (HRAS, NRAS, and KRAS) lead to constitutive activity of oncoproteins responsible for tumorigenesis and cancer progression. The targeting of RAS with drugs is challenging because RAS lacks classic and tractable drug binding sites. Over the past 30 years, this perception has led to the pursuit of indirect routes for targeting RAS expression, processing, upstream regulators, or downstream effectors. After the discovery t...
#1Juliette Paillet (Université Paris-Saclay)H-Index: 5
#2Céleste Plantureux (Université Paris-Saclay)H-Index: 1
Last. Sylvie Lachkar (Institut Gustave Roussy)H-Index: 25
view all 36 authors...
Cholangiocarcinoma (CCA) results from the malignant transformation of cholangiocytes. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are chronic diseases in which cholangiocytes are primarily damaged. Although PSC is an inflammatory condition predisposing to CCA, CCA is almost never found in the autoimmune context of PBC. Here, we hypothesized that PBC might favor CCA immunosurveillance. In preclinical murine models of cholangitis challenged with syngeneic CCA, PBC (b...
#1Laurence Zitvogel (Institut Gustave Roussy)H-Index: 139
#2Guido Kroemer (Institut Gustave Roussy)H-Index: 261
In this Journal Club, Zitvogel and Kroemer discuss a landmark study that initiated the genetic and molecular characterization of the immune–microbiota crosstalk.
#1Xin Chen (UTSW: University of Texas Southwestern Medical Center)H-Index: 11
#2Rui Kang (UTSW: University of Texas Southwestern Medical Center)H-Index: 30
Last. Daolin Tang (Guangzhou Medical University)H-Index: 27
view all 4 authors...
Pancreatic ductal adenocarcinoma (PDAC) remains an aggressive malignancy with a 5-year survival rate below 10%. Its unique genetic makeup and tumor microenvironment produce a lack of response to current treatments, including chemotherapy, radiotherapy, and immunotherapy. Recent preclinical studies have revealed that ferroptosis, an iron-dependent form of nonapoptotic cell death driven by unrestricted lipid peroxidation, may be an attractive therapeutic goal in PDAC. Understanding the dual role o...
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