Modifying the Conventional Visual Field Test Pattern to Improve the Detection of Early Glaucomatous Defects in the Central 10

Published on Oct 1, 2014in Translational Vision Science & Technology3.283
· DOI :10.1167/TVST.3.6.6
Ali S. Raza24
Estimated H-index: 24
(Columbia University)
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Abstract
Purpose To simulate modified versions of the 24-2 (6° grid) visual field (VF) test pattern by adding points from the 10-2 (2° grid) test pattern, and to assess their ability to detect early glaucomatous defects in the central 10°.
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6 Authors (Ali S. Raza)
References12
Newest
Purpose To use high-density perimetry to test a model of local glaucomatous damage to the macula (central visual field [VF]) and to assess the optimal placement of stimuli used to detect this damage.
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#3Ali S. Raza (Columbia University)H-Index: 24
Importance The macula is essential for visual functioning and is known to be affected even in early glaucoma. However, little is currently understood about the prevalence and nature of central vision loss in early glaucoma. Objective To determine the prevalence and characteristics of visual field (VF) defects in the central 10° in glaucoma suspects and patients with mild glaucoma using a prospective design. Design, Setting, and Participants This prospective observational cohort study was conduct...
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Purpose. To better understand the nature of early glaucomatous damage of the macula by comparing the results from 10-2 visual fields, optical coherence tomography (OCT) macular cube scans, and OCT circumpapillary circle scans.
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There is a growing body of evidence that early glaucomatous damage involves the macula. The anatomical basis of this damage can be studied using frequency domain optical coherence tomography (fdOCT), by which the local thickness of the retinal nerve fiber layer (RNFL) and local retinal ganglion cell plus inner plexiform (RGC+) layer can be measured. Based upon averaged fdOCT results from healthy controls and patients, we show that: 1. For healthy controls, the average RGC+ layer thickness closel...
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Objective To compare loss in sensitivity measured using standard automated perimetry (SAP) with local retinal ganglion cell layer (RGC) thickness measured using frequency-domain optical coherence tomography in the macula of patients with glaucoma. Methods To compare corresponding locations of RGC thickness with total deviation (TD) of 10-2 SAP for 14 patients with glaucoma and 19 controls, an experienced operator hand-corrected automatic segmentation of the combined RGC and inner plexiform layer...
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Preserving central vision is of paramount importance in treating glaucoma. However, it is fair to say we know more about paracentral damage than we do about damage to this most important region for visual function. This is in part due to the fact that visual field (VF) damage is commonly assessed with standard automated perimetry (SAP) and the 24-2 test. The 24-2 test pattern has only four points within the central 4.2° (radius) of fixation and only one point within the fovea, which is optional....
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#1Jesse Richman (Wills Eye Institute)H-Index: 9
Last. George L. SpaethH-Index: 73
view all 7 authors...
Objective To determine which aspects of vision most influence the ability of patients with glaucoma to function. Methods A total of 192 patients with a full range of glaucomatous visual loss were selected from the Glaucoma Service of Wills Eye Institute. Patients were evaluated clinically with standard visual assessments: visual acuity, contrast sensitivity, visual field, stereopsis, the Disc Damage Likelihood Scale, and intraocular pressure. Patients were evaluated objectively using a comprehen...
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#1Ulrich Schiefer (University of Tübingen)H-Index: 32
#2Eleni Papageorgiou (University of Tübingen)H-Index: 15
Last. J. Paetzold (University of Tübingen)H-Index: 16
view all 7 authors...
Typical glaucomatous visual field loss is characterized by arcuate defects, nasal steps, and other patterns corresponding to the course of retinal nerve fibers that respect the nasal horizontal meridian and usually spare the visual field center.1–5 Damage to the immediate paracentral visual field, leading to a so-called split fixation, is usually understood as a sign of advanced loss in cases of end-stage glaucomatous damage.6 In conventional perimetry, rectangular test point arrangements with a...
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#9Ali S. Raza (Columbia University)H-Index: 24
A novel automated boundary segmentation algorithm is proposed for fast and reliable quantification of nine intra-retinal boundaries in optical coherence tomography (OCT) images. The algorithm employs a two-step segmentation schema based on gradient information in dual scales, utilizing local and complementary global gradient information simultaneously. A shortest path search is applied to optimize the edge selection. The segmentation algorithm was validated with independent manual segmentation a...
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#1Patricia Nelson (Princess Alexandra Eye Pavilion)H-Index: 7
#2Peter AspinallH-Index: 32
Last. Colm O'BrienH-Index: 47
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PurposeThe aims of this study were (a) to explore patients self-reported visual disability resulting from glaucoma by means of a questionnaire developed for this purpose; (b) identify activities strongly associated with a measure of visual field loss, (c) to quantify different psychophysical aspects
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Cited By28
Newest
#1Vasanth Muthusamy (University of Melbourne)H-Index: 1
#2Andrew Turpin (University of Melbourne)H-Index: 33
Last. Allison M McKendrick (University of Melbourne)H-Index: 30
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Purpose null Information regarding the views of patients, on visual field testing is limited, and no information exists regarding their preferences for test developments. This study aimed to increase knowledge of patients’ experiences of visual field assessment and to explore their opinions and priorities regarding current areas of research and development. null null null Design null Online questionnaire with purposive sampling design. null null null Participants null Adults who regularly underg...
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#1Giovanni Montesano (UCL Institute of Ophthalmology)H-Index: 11
#2Allison M McKendrick (University of Melbourne)H-Index: 30
Last. Luca Rossetti (University of Milan)H-Index: 32
view all 12 authors...
Abstract null null Purpose null to evaluate the ability of additional central testing locations to improve detection of macular visual field (VF) defects in glaucoma. null null null Design null prospective cross-sectional study. null null null Participants null 440 healthy people and 499 patients with Glaucomatous Optic Neuropathy (GON) were tested with a fundus tracked perimeter (CMP, CenterVue, Italy) using a 24-2 grid with 12 additional macular locations (24-2+). null null null Methods null G...
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#1Tutul Chakravarti (UCSD: University of California, San Diego)H-Index: 2
#2Mohamad MoghadamH-Index: 1
Last. Linda M. ZangwillH-Index: 96
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PRECI Moderate to substantial agreement between 10-2 and 24-2C perimetry for detecting central field defects suggests that adding central test points to the 24-2 protocol may improve efficiency of visual field testing for glaucoma management. PURPOSE To assess agreement between Humphrey Visual Field Analyzer 10-2 and 24-2C test protocols for detecting glaucomatous defects in the central 10° of the visual field (CVFDs). METHODS VFs from 165 eyes of 18 healthy individuals, 12 glaucoma suspects and...
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#1Michael Sullivan-Mee (Veterans Health Administration)H-Index: 13
Last. Denise PensylH-Index: 5
view all 7 authors...
PRECIS Using standard glaucoma structural and functional tests, clinicians accurately predicted presence/absence of 10-2 glaucomatous VF loss in 90% of the eyes in this study. PURPOSE To investigate how well clinicians with variable experience can predict presence and location of 10-2 visual field loss using structural and functional data that is routinely obtained for glaucoma assessment. METHODS Within a test set of 416 eyes (210 subjects) who were diagnosed glaucoma suspect or primary open-an...
Source
#1Michael E. West (Nova Scotia Health Authority)H-Index: 2
#2Glen P. Sharpe (Nova Scotia Health Authority)H-Index: 18
Last. Balwantray C. Chauhan (Nova Scotia Health Authority)H-Index: 4
view all 8 authors...
Purpose To determine whether the 10-2 test of the Humphrey Field Analyzer detected a higher proportion of abnormal visual fields compared with the 24-2 test in the central 10° of patients with early glaucomatous visual field damage. Design Prospective observational study. Participants Patients with open-angle glaucoma and healthy control participants. Methods All participants underwent a 24-2 and 10-2 test. Only the 12 central test locations of the 24-2 test were included to analyze equivalent v...
Source
#1Adi OrbachH-Index: 1
#2Ghee Soon AngH-Index: 23
Last. Zhichao Wu (University of Melbourne)H-Index: 22
view all 11 authors...
ABSTRACT Purpose : To examine whether glaucomatous central visual field abnormalities can be more effectively detected using a qualitative, expert evaluation of the 10-2 test compared to the topographically corresponding central 12 locations of the 24-2 test (C24-2). Design : Cross-sectional study. Methods : Eyes with a glaucomatous optic nerve appearance or ocular hypertension (n = 523) and healthy eyes (n = 107) were included as cases and controls respectively. The 10-2 and C24-2 visual field ...
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#1Kyoung In Jung (Catholic University of Korea)H-Index: 13
#2Hee Kyung Ryu (Catholic University of Korea)H-Index: 1
Last. Chan Kee Park (Catholic University of Korea)H-Index: 28
view all 5 authors...
Using either 24-2 or 10-2 visual field (VF) testing only is not enough to cover all the various types of glaucomatous VF defects. We investigated the performance of the combined 24-2 and 10-2 perimetry when conducted together and separately using the structure-function relationship. A total of 30 glaucoma patients with isolated peripheral nasal step, 37 patients with isolated paracentral scotoma, and 38 patients with both paracentral and nasal scotoma were included. To create the combined Humphr...
Source
#1Maya L.M. Yamane (UCSD: University of California, San Diego)
#2Jeffrey G Odel (UCSD: University of California, San Diego)
PURPOSE The Humphrey 24-2C visual field test is a modified 24-2 visual field test that incorporates 10 additional test points in the central 10° of vision. This study compares the new 24-2C test to the standard Humphrey 10-2 visual field test in patients presenting for neuro-ophthalmology evaluation to evaluate its ability to detect central visual field defects. METHODS Twenty-five neuro-ophthalmology patients (42 eyes) underwent both 24-2C and 10-2 visual field testing using the Humphrey perime...
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#1Jack Phu (UNSW: University of New South Wales)H-Index: 11
#2Michael Kalloniatis (UNSW: University of New South Wales)H-Index: 36
Abstract Purpose To compare the ability of 24-2 and 24-2C test grids in measuring visual field global indices, identifying central visual field defects and facilitating macular structure-function analysis with optical coherence tomography (OCT) scans in glaucoma suspects and glaucoma patients. Design Prospective, cross-sectional study Participants One eye from 100 glaucoma suspect and glaucoma patients (60 undergoing SITA-Faster testing on 24-2 and 24-2C; 40 undergoing SITA-Standard testing on 2...
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#1Vahid Mohammadzadeh (UCLA: University of California, Los Angeles)H-Index: 3
#2Nima Fatehi (UCLA: University of California, Los Angeles)H-Index: 5
Last. Kouros Nouri-Mahdavi (UCLA: University of California, Los Angeles)H-Index: 32
view all 8 authors...
With the advent of spectral-domain optical coherence tomography (SD-OCT), imaging of the posterior segment of the eye can be carried out rapidly at multiple anatomical locations, including the optic nerve head (ONH), circumpapillary retinal nerve fiber layer (cp-RNFL), and macula. There is now ample evidence to support the role of SD-OCT imaging of the macula for detection of early glaucoma. Macular SD-OCT measurements demonstrate high reproducibility, and evidence on its utility for detection o...
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