Translational Vision Science & Technology
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Newest
#1Lewis Karapanos (University of Melbourne)
#2Carla J Abbott (University of Melbourne)H-Index: 9
Last. William Kentler (University of Melbourne)H-Index: 2
view all 14 authors...
Purpose In a clinical trial (NCT03406416) of a second-generation (44-channel) suprachoroidal retinal prosthesis implanted in subjects with late-stage retinitis pigmentosa (RP), we assessed performance in real-world functional visual tasks and emotional well-being. Methods The Functional Low-Vision Observer Rated Assessment (FLORA) and Impact of Vision Impairment-Very Low Vision (IVI-VLV) instruments were administered to four subjects before implantation and after device fitting. The FLORA contai...
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#1Weihao Chen (Miami University)
#2Georgios Tsissios (Miami University)
Last. Katia Del Rio-Tsonis (Miami University)H-Index: 28
view all 8 authors...
Purpose To establish optical coherence tomography (OCT) as an in vivo imaging modality for investigating the process of newt lens regeneration. Methods Spectral-domain OCT was employed for in vivo imaging of the newt lens regeneration process. A total of 37 newts were lentectomized and followed by OCT imaging over the course of 60 to 80 days. Histological images were obtained at several time points to compare with the corresponding OCT images. Volume measurements were also acquired. Results OCT ...
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#1Ilham Putra (UIC: University of Illinois at Chicago)H-Index: 8
#2Xiang Shen (UIC: University of Illinois at Chicago)H-Index: 20
Last. Abdelrahman M. Elhusseiny (UIC: University of Illinois at Chicago)H-Index: 1
view all 19 authors...
Purpose Mesenchymal stromal cells (MSCs) have been shown to enhance tissue repair as a cell-based therapy. In preparation for a phase I clinical study, we evaluated the safety, dosing, and efficacy of bone marrow-derived MSCs after subconjunctival injection in preclinical animal models of mice, rats, and rabbits. Methods Human bone marrow-derived MSCs were expanded to passage 4 and cryopreserved. Viability of MSCs after thawing and injection through small-gauge needles was evaluated by vital dye...
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#1Luke E. Hallum (University of Auckland)H-Index: 15
#2Steven C. Dakin (University of Auckland)H-Index: 53
Purpose Retinitis pigmentosa (RP) is a hereditary disease causing photoreceptor degeneration and permanent vision loss. Retinal implantation of a stimulating electrode array is a new treatment for RP, but quantification of its efficacy is the subject of ongoing work. This review evaluates vision-related outcomes resulting from retinal implantation in participants with RP. Methods We searched MEDLINE and Embase for journal articles published since January 1, 2015. We selected articles describing ...
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#1Hannah Cobb (University of Colorado Denver)
#2Silvia Aparicio-Domingo (University of Colorado Denver)H-Index: 1
Last. M. Valeria Canto-Soler (University of Colorado Denver)H-Index: 11
view all 3 authors...
Translational Relevance Designing a GMP-compliant protocol for three-dimensional retinal organoid production is of urgent need in order to bring transplantation of hiPSC-derived retinal tissue and derived cells to clinical trials - and ultimately patient treatment - for retinal degenerative diseases.
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#1Steven Becker (NIH: National Institutes of Health)H-Index: 5
#2Santa J. Tumminia (NIH: National Institutes of Health)H-Index: 14
Last. Michael F. Chiang (NIH: National Institutes of Health)H-Index: 1
view all 3 authors...
Eight years since the launch of the National Eye Institute Audacious Goals Initiative for Regenerative Medicine, real progress has been made in the effort to restore vision by replacing retinal neurons. Although challenges remain, the infrastructure, tools, and preclinical models to support clinical studies in humans are being prepared. Building on the pioneering trials that are replacing the retinal pigment epithelium, it is expected that by the end of this decade first-in-human trials for the ...
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#1Michael L. Risner (VUMC: Vanderbilt University Medical Center)H-Index: 7
#2Silvia Pasini (VUMC: Vanderbilt University Medical Center)H-Index: 4
Last. David J. Calkins (VUMC: Vanderbilt University Medical Center)H-Index: 40
view all 7 authors...
Purpose Human retinal ganglion cells (hRGC) derived from human pluripotent stem cells are promising candidates to model, protect, and replace degenerating RGCs. Here, we examined intrinsic morphologic and physiologic development of hRGCs. Methods We used CRISPR-Cas9 to selectively express tdTomato under the RGC-specific promoter, BRN3B. Human pluripotent stem cells were chemically differentiated into hRGCs and cultured up to 7 weeks. We measured soma area, neurite complexity, synaptic protein, a...
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#1Suneel Gupta (MU: University of Missouri)H-Index: 1
#2Nishant Sinha (MU: University of Missouri)H-Index: 10
Last. Rajiv R. Mohan (MU: University of Missouri)H-Index: 43
view all 9 authors...
Purpose Tissue-targeted localized BMP7+HGF genes delivered into the stroma via nanoparticle effectively treats corneal fibrosis and rehabilitates transparency in vivo without acute toxicity. This study evaluated the long-term safety and tolerability of BMP7+HGF nanomedicine for the eye in vivo. Methods One eye each of 36 rabbits received balanced salt solution (group 1, naive; n = 12), naked vector with polyethylenimine-conjugated gold nanoparticles (PEI2-GNP; group 2, naked-vector; n = 12), or ...
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#1Rajiv R. Mohan (MU: University of Missouri)H-Index: 43
#2Praveen Balne (MU: University of Missouri)H-Index: 1
Last. Nathan P. Hesemann (MU: University of Missouri)H-Index: 7
view all 9 authors...
Purpose A significant remission of corneal fibrosis and neovascularization in rabbit eye in vivo was observed from a tissue-selective localized adeno-associated virus (AAV)5-Decorin (Dcn) gene therapy. This study sought to investigate 6-month toxicity profiling of this gene therapy for the eye in vivo using a rabbit model. Methods A small epithelial scrape followed by corneal drying was performed unilaterally in 12 rabbit eyes and either AAV5-Dcn (n = 6) or naked vector (n = 6) was delivered top...
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#1Tetsuya Komatsu (Toho University)H-Index: 2
#2Tomoaki Shiba (International University of Health and Welfare)
Last. Yuichi Hori (Toho University)H-Index: 25
view all 8 authors...
Purpose null To evaluate continuous variations of ocular microcirculation by laser speckle flowgraphy and those of regional stiffening by pulse wave velocity (PWV) and vascular resistance under systemic adrenaline administration in rabbits. null Methods null Six 16-week-old male rabbits were evaluated. The mean blur rates in the retinal vessel (MBR-RV) and choroid (MBR-CH) were measured. We assessed blood pressure (BP), femoral and carotid vascular resistance, and the heart-ankle (ha)-PWV, heart...
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Top fields of study
Ophthalmology
Glaucoma
Optical coherence tomography
Retinal
Medicine