An assessment of antigenic potential of β-lactam antibiotics, low molecular weight drugs, using guinea pig models

Allergic reactions are among the common adverse effects in humans. However, it is widely assumed that there are practically no reliable animal models for preclinical tests of low-molecular weight drugs that are available to predict such reactions. This study was designed to compare the detecting ability of test methods for antigenic potential of eight β-lactam antibiotics with which allergic outcome has been reported in humans. The tests...