Hiroyuki Hattori
Daiichi Sankyo
Internal medicineChemokineEndocrinologyAntigenTumor necrosis factor alphaImmunologyAllergyPrimary and secondary antibodiesAnaphylaxisT cellKeyhole limpet hemocyaninCytokineAntigenicityAntipyreticDrugToxicityLeukocyte migrationAntibioticsInterleukin 8MedicineBiologyImmune system
12Publications
6H-index
106Citations
Publications 11
Newest
#1Ryota Kawai (Daiichi Sankyo)H-Index: 4
#2Tetsuo Aida (Daiichi Sankyo)H-Index: 6
Last. Teruo Kawada (Kyoto University)H-Index: 64
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T-cell dependent antibody response (TDAR) incorporating both primary and secondary responses to keyhole limpet hemocyanin (KLH) in canine models have not yet been fully understood. To develop a practical dog TDAR model, we characterized primary and secondary antibody responses by intravenous or intramuscular immunization of KLH twice at intervals of 8 days during a 28-day course of study. Primary immunization with KLH by both routes induced a maximum IgM response on 6 to 8 days after the treatme...
6 CitationsSource
#1Yoshiharu Hiruma (Daiichi Sankyo)H-Index: 4
#2Eisuke Tsuda (Daiichi Sankyo)H-Index: 33
Last. Chie Fukuda (Daiichi Sankyo)H-Index: 4
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Abstract Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is a cell surface receptor for sialylated glycan ligands. Recent in vitro studies revealed upregulated Siglec - 15 expression in differentiated osteoclasts and inhibition of osteoclast differentiation by anti-Siglec-15 polyclonal antibody, demonstrating Siglec-15 involvement in osteoclastogenesis. To discern the physiological role of Siglec-15 in skeletal development and osteoclast formation and/or function in vivo , we gener...
42 CitationsSource
#1Ryota KawaiH-Index: 4
#2Shiho ItoH-Index: 1
Last. Teruo Kawada (Kyoto University)H-Index: 64
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To develop a rat T-cell-dependent antibody response (TDAR) model evaluating both primary and secondary antibody responses, keyhole limpet hemocyanin (KLH) was used to immunize rats twice during a 14-day course of study, a pattern closely linked to that of a short-term general toxicity study. Female rats of four representative strains (e.g., Sprague-Dawley, Wistar, Fischer, and Lewis) were immunized twice with intravenous administrations of KLH (300 µg/rat) on Days 5 and 9 during a 14-day treatme...
18 CitationsSource
#2Motohiro YagiH-Index: 4
Last. Katsuji UnoH-Index: 5
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Background: The leukocyte migration test (LMT) is effective in identifying the causative drug in drug allergies. Both leukocyte migration activating activity (LMAA) and leukocyte migration inhibitory activity (LMIA) are involved in the development of drug allergies. However, no cytokines associated with LMIA have been identified to date. Because CXCL8 played an important role in neutrophil infiltration and activation, we performed the LMT and measured CXCL8 levels in patients with hypersensitivi...
#1Manabu Abe (Niigata University of Pharmacy and Applied Life Sciences)H-Index: 3
#2Motohiro YagiH-Index: 4
Last. Katsuji Uno (Fukuyama University)H-Index: 4
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ABSTRACT Background The leukocyte migration test (LMT) is effective in identifying the causative drug in drug allergies. Both leukocyte migration activating activity (LMAA) and leukocyte migration inhibitory activity (LMIA) are involved in the development of drug allergies. However, no cytokines associated with LMIA have been identified to date. Because CXCL8 played an important role in neutrophil infiltration and activation, we performed the LMT and measured CXCL8 levels in patients with hypers...
5 CitationsSource
#1Masako Imaoka (Daiichi Sankyo)H-Index: 7
#2Michiyuki Kato (Daiichi Sankyo)H-Index: 6
Last. Sunao Manabe (Daiichi Sankyo)H-Index: 17
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The effect of rat albumin (RALB) on D-galactosamine (GalN) hepatotoxicity was investigated in male Crl:CD(SD) rats aged 6 weeks. The animals were divided into control, RALB, GalN, and RALB + GalN groups. GalN (800 mg/kg) was intraperitoneally administered immediately after an intravenous injection of RALB (100 mg/kg). The animals were euthanized 6 or 24 h later and subjected to laboratory investigations and histological examinations of the liver. Furthermore, in order to determine the contributi...
2 CitationsSource
#1Hiroyuki Hattori (Daiichi Sankyo)H-Index: 6
#2Michiyuki Kato (Daiichi Sankyo)H-Index: 6
Last. Sunao Manabe (Daiichi Sankyo)H-Index: 17
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This study was performed to develop mouse anaphylaxis model using ovalbumin (OA) as an antigen, with no adjuvant, and an intravenous route of administration. OA at dose levels from 0.5 to 500 mg/kg was injected 3 times into the tail vein of female CD-1 (ICR) mice at 4-day intervals. Clinical signs and extravasation of Evans blue dye (vascular permeability) were observed, serum histamine levels and airway resistance were measured, and histopathological examinations were performed. Furthermore, to...
2 CitationsSource
#1Hiroyuki Hattori (Kitasato University)H-Index: 6
#2Hirotaka Imai (Kitasato University)H-Index: 21
Last. Yasuhito Nakagawa (Kitasato University)H-Index: 35
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In the present study we investigated promoter regions of the PHGPx [phospholipid hydroperoxide GPx (glutathione peroxidase)] gene and transcription factors involved in TNFα (tumour necrosis factor α)-induced up-regulation of PHGPx in non-differentiated HL60 cells. Non-differentiated HL60 cells displayed up-regulation of non-mitochondrial and mitochondrial PHGPx mRNA in response to TNFα stimulation. The promoter activity was up-regulated by TNFα stimulation in cells transfected with a luciferase ...
12 CitationsSource
#1Hiroyuki HattoriH-Index: 6
#2Fumie YamaguchiH-Index: 3
Last. Mamoru NomuraH-Index: 8
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Allergic reactions are among the common adverse effects in humans. However, it is widely assumed that there are practically no reliable animal models for preclinical tests of low-molecular weight drugs that are available to predict such reactions. This study was designed to compare the detecting ability of test methods for antigenic potential of eight β-lactam antibiotics with which allergic outcome has been reported in humans. The tests included active systemic anaphylaxis (ASA), delayed type s...
10 CitationsSource
#1Hiroyuki HattoriH-Index: 6
#2Fumie YamaguchiH-Index: 3
Last. Hiroshi OhnoH-Index: 79
view all 4 authors...