Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs)

Paradigm I: the haematopoietic niche Paradigm II: engraftment/differentiation Paradigm III: transient ‘quasi‐niches’ Conclusions/perspectives In this review, we focus on the adult stem/progenitor cells that were initially isolated from bone marrow and first referred to as colony forming units‐fibroblastic, then as marrow stromal cells and subsequently as either mesenchymal stem cells or multipotent mesenchymal stromal cells (MSCs). The current...