Original paper

A Systems Approach to Mapping DNA Damage Response Pathways

Science44.70
Volume: 312, Issue: 5776, Pages: 1054 - 1059
Published: May 19, 2006
Abstract
Failure of cells to respond to DNA damage is a primary event associated with mutagenesis and environmental toxicity. To map the transcriptional network controlling the damage response, we measured genomewide binding locations for 30 damage-related transcription factors (TFs) after exposure of yeast to methyl-methanesulfonate (MMS). The resulting 5272 TF-target interactions revealed extensive changes in the pattern of promoter binding and...
Paper Details
Title
A Systems Approach to Mapping DNA Damage Response Pathways
Published Date
May 19, 2006
Journal
Volume
312
Issue
5776
Pages
1054 - 1059
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