A4.5 Procollagen type 1 amino-terminal propeptide is negatively associated with bone stiffness in subpopulations of patients submitted to hip replacement surgery

Background and Objectives

Osteoporosis (OP) is a frequent disorder of bone metabolism. In OP, cortical bone changes lead to bone loss and deterioration of the microarchitecture increasing risk of fragility fractures of the hip. Bone turnover markers (BTM) reflect bone remodelling. Their role in daily clinical practice is still undefined. In a recent epidemiologic study, a relation between P1NP and hip fractures was found, suggesting...