Guide to Receptors and Channels (GRAC), 3rd edition.

Published on Mar 1, 2008in British Journal of Pharmacology7.73
· DOI :10.1038/SJ.BJP.0707746
Stephen P.H. Alexander56
Estimated H-index: 56
(University of Nottingham),
Alistair Mathie43
Estimated H-index: 43
(UKC: University of Kent),
John A. Peters73
Estimated H-index: 73
The Fifth Edition of the ‘Guide to Receptors and Channels’ is a compilation of the major pharmacological targets divided into seven sections: G protein-coupled receptors, ligand-gated ion channels, ion channels, catalytic receptors, nuclear receptors, transporters and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside suggestions for further reading. Available alongside this publication is a portal at which is produced in close association with NC-IUPHAR and allows free online access to the information presented in the Fifth Edition.
📖 Papers frequently viewed together
2,459 Citations
1,282 Citations
10.6k Citations
#1Paul M. VanhoutteH-Index: 6
#2P P HumphreyH-Index: 2
Last. Michael SpeddingH-Index: 65
view all 3 authors...
65 Citations
Cited By2985
#1Shiyun PuH-Index: 8
#2Yanping LiH-Index: 11
Last. Jinhan HeH-Index: 25
view all 17 authors...
Background and purpose: Activation of hepatic stellate cells (HSC) is a central driver of liver fibrosis. 5-lipoxygenase (5-LO) is the key enzyme that catalyzes arachidonic acid to leukotrienes. In this study, we examined the role of 5-LO in HSC activation and liver fibrosis. Main methods: Culture medium was collected from quiescent and activated HSC for target metabolomics analysis. Exogenous leukotrienes were added to culture medium to explore its effect in activating HSC. Genetic ablation of ...
#1Aleksandra Szopa (Medical University of Lublin)H-Index: 10
#2Katarzyna Socała (UMCS: Maria Curie-Skłodowska University)H-Index: 13
Last. Piotr Wlaź (UMCS: Maria Curie-Skłodowska University)H-Index: 25
view all 7 authors...
Abstract Purinergic signaling involves the actions of purine nucleotides and nucleosides (such as adenosine) at P1 (adenosine), P2X, and P2Y receptors. Here, we present recent data contributing to a comprehensive overview of the association between purinergic signaling and depression. We start with background information on adenosine production and metabolism, followed by a detailed characterization of P1 and P2 receptors, with an emphasis on their expression and function in the brain as well as...
1 CitationsSource
#1Xiaohui Liu (Kyushu University)H-Index: 9
#2Keitaro Suyama (Kyushu University)H-Index: 4
Last. Yasuyuki Shimohigashi (Kyushu University)H-Index: 28
view all 5 authors...
We reported that bisphenol AF (BPAF) works as an agonist for estrogen receptor (ER) ERα but as an antagonist for ERβ. Similar results were observed for bisphenol E analogs (BPE-X) such as BPE-F, BPE-Cl, and BPE-Br, each consisting of a series of a tri-halogenated methyl group CX3 in the central alkyl moiety. It was demonstrated that the electrostatic halogen bond based on the dispersion force of halogen atoms is a major driving force in the activities of bifunctional ERα-agonist and ERβ-antagoni...
1 CitationsSource
Since March 2020, the world has been fighting a global pandemic caused by a new coronavirus SARS-CoV-2 (COVID-19). SARS-CoV-2 is responsible for severe acute respiratory syndrome, an airway disease that can be severe and fatal in a percentage of cases. Patients with severe COVID-19 can develop extrapulmonary lesions, with renal, hepatic, cardiac, neurological, and tissue involvement that can cause further severe complications. On December 21, 2021, the European Medicines Agency (EMA) authorized ...
3 CitationsSource
Breast cancer is the main cause of morbidity and mortality in women worldwide. However, the molecular pathogenesis of breast cancer remains poorly defined due to its heterogeneity. Several studies have reported that G Protein-Coupled Estrogen Receptor 1 (GPER1) plays a crucial role in breast cancer progression, by binding to estrogens or synthetic agonists, like G-1, thus modulating genes involved in diverse biological events, such as cell proliferation, migration, apoptosis, and metastasis. In ...
#1Mingming Yang (SEU: Southeast University)H-Index: 1
#1Mingming Yang (SEU: Southeast University)
Last. John M. QuayleH-Index: 18
view all 4 authors...
Abstract Cardiomyopathy is among the major clinical manifestations of heart diseases that triggers malfunctioning of the cardiovascular system. Some of the major causal factors of cardiomyopathy includes myocardial ischemia, drug-toxicity, genetic aberrations, abnormal depositions of essential elements, and redox imbalance. Diabetes, being the major comorbid of cardiovascular diseases and vice versa, further enhances the progress of cardiomyopathy. The molecular mechanisms of action suggest that...
1 CitationsSource
#1Lizhu Tang (CAS: Chinese Academy of Sciences)H-Index: 3
#2Mengyuan Liu (CAS: Chinese Academy of Sciences)H-Index: 2
Last. Lianguo Chen (CAS: Chinese Academy of Sciences)H-Index: 15
view all 7 authors...
Abstract Perfluorobutane sulfonate (PFBS), an environmental pollutant of emerging concern, is previously shown to dynamically interact with hypoxia on aquatic developmental toxicities. However, the molecular mechanisms underlying the interaction remain unknown. In this follow-up study, marine medaka embryos were exposed to 0 and 3.3 mg/L of PFBS under normoxia (6.9 mg/L) or hypoxia (1.7 mg/L) condition till 15 days post-fertilization. High-throughput transcriptomic sequencing was employed to fil...
1 CitationsSource
Current therapies for the treatment of chronic pain provide inadequate relief for millions of suffering patients, demonstrating the need for better therapies that will treat pain effectively and improve the quality of patient's lives. Better understanding of the mechanisms that mediate chronic pain is critical for developing drugs with improved clinical outcomes. Adenosine triphosphate (ATP) is a key modulator in nociceptive pathways. Release of ATP from injured tissue or sympathetic efferents h...
4 CitationsSource