DIFFERENTIAL CONTRIBUTION OF β-ADRENERGIC RECEPTORS EXPRESSED ON RADIOSENSITIVE VERSUS RADIORESISTANT CELLS TO PROTECTION AGAINST INFLAMMATION AND MORTALITY IN MURINE ENDOTOXEMIA

The sympathetic nervous system modulates immune responses via the secretion of catecholamines and subsequent activation of adrenergic receptors (ARs), and systemic catecholamine levels increase markedly in the setting of endotoxemia and sepsis. Previous studies have demonstrated that stimulation of β-ARs by pharmacological agonists attenuates the inflammatory response to LPS observed in vitro and can increase survival in animal models of...