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#1Reinaldo Salomão (UNIFESP: Federal University of São Paulo)H-Index: 35
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#1Aysegül Temiz Artmann (İzmir Institute of Technology)
Last. Gerhard M. ArtmannH-Index: 20
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BACKGROUND Septic cardiomyopathy (SCM) increases mortality by 70-90% and results in mechanical dysfunction of cells. METHODS Here, we created a lipopolysaccharide (LPS) -induced in-vitro sepsis model with mouse embryonic stem cell-derived cardiomyocytes (mESC-CM) using the CellDrum technology which simultaneously measures mechanical compliance and beat frequency of mESCs. Visualization of reactive oxygen species (ROS), actin stress fibers, and mRNA quantification of endothelial protein C recepto...
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#1Yoshifumi Naito (Kyoto Prefectural University of Medicine)H-Index: 9
#2Hideya KatoH-Index: 6
Last. Jae-Woo LeeH-Index: 29
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ABSTRACT Extracellular vesicles (EVs) have now been recognized as important mediators of cellular communication during injury and repair. We previously found that plasma EVs isolated from ex vivo perfused human lungs injured with Escherichia coli bacterial pneumonia were inflammatory, and exogenous administration of high molecular weight (HMW) hyaluronic acid (HA) as therapy bound to these EVs, decreasing inflammation and injury. In the current study, we studied the role of EVs released during s...
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#1Sang-Min KimH-Index: 9
#2Sang-Il KimH-Index: 2
Last. Won Young KimH-Index: 26
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#1Likai ShiH-Index: 1
Last. Qiang FuH-Index: 37
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#1Robert T. MankowskiH-Index: 13
#2Orlando LaitanoH-Index: 12
Last. Ryan M. ThomasH-Index: 26
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#1Yuzhuo ZhaoH-Index: 2
#2Lijing JiaH-Index: 3
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#1Nan CaiH-Index: 1
Last. Fei He
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#1Martin FrydlandH-Index: 9
#1Martin FrydlandH-Index: 2
Last. Christian HassagerH-Index: 78
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Top fields of study
Endocrinology
Chemistry
Immunology
Resuscitation
Sepsis
Anesthesia
Diabetes mellitus
Medicine