Gelatinase B–deficient Mice Are Resistant to Experimental Bullous Pemphigoid
Abstract
Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterized by deposition of autoantibodies at the basement membrane zone. In an experimental BP model in mice, the subepidermal blistering is mediated by antibodies directed against the hemidesmosomal protein BP180 (collagen XVII, BPAG2), and depends on complement activation and neutrophil infiltration. Gelatinase B is present in BP blister fluid and can cleave BP180. In...
Paper Details
Title
Gelatinase B–deficient Mice Are Resistant to Experimental Bullous Pemphigoid
Published Date
Aug 3, 1998
Volume
188
Issue
3
Pages
475 - 482
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