Macrophage Diversity Enhances Tumor Progression and Metastasis
Abstract
There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression. During tumor initiation, they create an inflammatory environment that is mutagenic and promotes growth. As tumors progress to malignancy, macrophages stimulate angiogenesis, enhance tumor cell migration and invasion, and suppress antitumor immunity. At metastatic sites, macrophages prepare the target tissue for arrival of...
Paper Details
Title
Macrophage Diversity Enhances Tumor Progression and Metastasis
Published Date
Apr 1, 2010
Journal
Volume
141
Issue
1
Pages
39 - 51
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